FM19G11

Catalog # Availability Size / Price Qty
6653/5
6653/25
FM19G11 | CAS No. 329932-55-0 | HIF Inhibitors
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Description: HIF α-subunit inhibitor

Chemical Name: 2-Oxo-2-(p-tolyl)ethyl 3-(2,4-dinitrobenzamido)benzoate

Purity: ≥98%

Product Details
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Biological Activity

Hypoxia inducible factor (HIF) α-subunit inhibitor (IC50 = 80 nM in hypoxia induced luciferase assay). Inhibits transcriptional activity of HIFα isoforms. Directly regulates expression and inhibits transcriptional activity of pluripotency markers (Sox2 and Oct4) in rodent and human stem cells under hypoxic conditions, driving differentiation. Improves locomotion after severe spinal cord injury in mice, alone or in combination with transplantation of ependymal stem cells of the spinal cord. Also inhibits O6-methylguanine DNA methyltransferase (MGMT) via HIF1α pathway, under normal and hypoxic conditions in glioblastoma cell lines.

Technical Data

M.Wt:
463.4
Formula:
C23H17N3O8
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
329932-55-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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