FMF-04-159-R

Catalog # Availability Size / Price Qty
7159/10
FMF-04-159-R | Cyclin-dependent Kinase Inhibitors
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Description: Potent CDK14 and CDK16 inhibitor; displays reversible inhibition of CDK14

Chemical Name: N-(1-((3-(4-(Dimethylamino)butanamido)phenyl)sulfonyl)piperidin-4-yl)-4-(2,4,6-trichlorobenzamido)-1H-pyrazole-3-carboxamide

Purity: ≥98%

Product Details
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Biological Activity

FMF-04-159-R is a potent inhibitor of CDK16 and CDK14 (IC50 values are 6 and 140 nM, respectively in kinase activity assay; IC50 = 563 nM for CDK14 in BRET assay). Also binds CDK2 (IC50 = 493 nM). Inhibition reversible upon compound wash-out. Control for FMF-04-159-2 (Cat. No. 7158).

Technical Data

M.Wt:
685.02
Formula:
C28H32Cl3N7O5S
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Discovery of covalent CDK14 inhibitors with pan-TAIRE family specificity.
    Ferguson et al.
    Cell Chem.Biol., 2019;26:804

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