Fmk

Catalog # Availability Size / Price Qty
4690/10
Cat.No. 4690 - Fmk | C18H19FN4O2 | CAS No. 821794-92-7
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Description: Irreversible ribosomal S6 kinase inhibitor 1/2 inhibitor

Chemical Name: 1-[4-Amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-fluoroethanone

Purity: ≥97%

Product Details
Reviews

Biological Activity

Potent irreversible RSK1/2 inhibitor (IC50 = 15 nM). Inactivates the C-terminal auto-kinase domain activity. Suppresses RSK2 kinase activity in RSK2-expressing HNSCC cell lines. Reduces HNSCC cell invasive ability. Displays no effect on EGF-stimulated phosphorylation of ERK1 or ERK2.

Technical Data

M.Wt:
342.37
Formula:
C18H19FN4O2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥97%
Storage:
Store at -20°C
CAS No:
821794-92-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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