Key Product Details

Species Reactivity

Mouse

Applications

Flow Cytometry, CyTOF-ready

Label

FITC (Excitation = 495 nm, Emission = 519 nm)

Antibody Source

Monoclonal Rat IgG2b Kappa Clone # TH6
View all FOLR4 Primary Antibodies »

Product Specifications

Immunogen

CD3 mAb-stimulated CD4/25 T cells

Clonality

Monoclonal

Host

Rat

Isotype

IgG2b Kappa

Applications for FOLR4 Antibody (TH6) [FITC]

Application
Recommended Usage

CyTOF-ready

Optimal dilutions of this antibody should be experimentally determined.

Flow Cytometry

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Spectra Viewer

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Flow Cytometry

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: FOLR4

Folates represent an important role in protein and nucleic acid biosynthesis and are recognized in particular for their role in spinal canal and brain development during early pregnancy. Recently, Yamaguchi et al, 2007 have shown that Folate receptor 4 (FR4), a subtype of the receptor for the vitamin folic acid is expressed at high levels in both natural and TGF-b-induced Treg cells. A majority of the CD4+ Tregs express Folate receptor 4 along with CD25 and FoxP3. In addition, there are functional similarities in regulating immune response by FoxP3 and FR4 expressing CD4+ Tregs which express CD25 as well. CD4+/25+FR4hi T cell population may be used as a functional immuno-suppressor Treg population which should express FoxP3. Folate receptor 4 may be considered as a surface marker for Tregs. The antibody produced by clones 12A5 and TH6 recognize FR4 in Tregs. FR4 is also known as folate receptor delta and folate-binding protein 3. FR4 antibody in combination with CD4/25 antibody may be used for isolation (both FACS and magnetic beads sorting) and staining of Tregs using simple surface staining while keeping the Tregs viable for subsequent down stream applications. Folate receptor 4 is known to be expressed exclusively in lymphoid tissues.

Long Name

Folate Receptor 4

Alternate Names

FR-delta, LOC390243

Gene Symbol

IZUMO1R

Additional FOLR4 Products

Product Documents for FOLR4 Antibody (TH6) [FITC]

Certificate of Analysis

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Product Specific Notices for FOLR4 Antibody (TH6) [FITC]

This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Related Research Areas

Cancer Biomarkers

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