Formoterol hemifumarate

  ( 8 citations )    
Product Datasheet
Catalog Number:1448
Alternate Names:BD 40A
Chemical Name:(±)-(R,R)-N-[2-Hydroxy-5-[1-hydroxy-2-[[2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl] formamide hemifumarate
Product Details
Citations (8)
Supplemental Products
Reviews
Biological Activity
Potent, selective and long-acting β2-adrenoceptor agonist. Displays 330-fold selectivity for β2 over β1 receptors (pKd values are 8.12 and 5.58 respectively). Potently relaxes guinea pig trachea (pD2 = 9.29), and is longer-acting and 100-fold more potent than salbutamol.
Technical Data
  • M.Wt:
    402.45
  • Formula:
    C19H24N2O4.½C4H4O4
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
    >99
  • Storage:
    Store at RT
  • CAS No:
    43229-80-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Formoterol hemifumarate include:

8 Citations: Showing 1 - 8
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  1. β2-adrenoreceptor Inverse Agonist Down-regulates Muscarine Cholinergic Subtype-3 Receptor and Its Downstream Signal Pathways in Airway Smooth Muscle Cells in vitro.
    Authors: Luo
    Scientific Reports  2017;7:39905
  2. β2-adrenoreceptor stimulation dampens the LPS-induced M1 polarization in pig macrophages.
    Authors: Bacou
    Dev Comp Immunol  2017;76:169
  3. β2-Adrenergic Receptor Antagonism Attenuates CNV Through Inhibition of VEGF and IL-6 Expression.
    Authors: Lavine
    Invest Ophthalmol Vis Sci  2017;58(1):299
  4. The β2-adrenoceptor activates a positive cAMP-calcium feedforward loop to drive breast cancer cell invasion.
    Authors: Pon Et al.
    FASEB J  2016;30:1144
  5. A long-acting β2-adrenergic agonist increases the expression of muscarine cholinergic subtype-3 receptors by activating the β2-adrenoceptor cyclic adenosine monophosphate signaling pathway in airway smooth muscle cells.
    Authors: Liu Et al.
    Mol Cell Neurosci  2015;11:4121
  6. Attenuation of choroidal neovascularization by β(2)-adrenoreceptor antagonism.
    Authors: Lavine Et al.
    JAMA Ophthalmol  2013;131:376
  7. Ectopic activity in the rat pulmonary vein can arise from simultaneous activation of alpha1- and beta1-adrenoceptors.
    Authors: Maupoil Et al.
    Br J Pharmacol  2007;150:899
  8. Expression of inwardly rectifying potassium channels (GIRKs) and beta-adrenergic regulation of breast cancer cell lines.
    Authors: Plummer Et al.
    BMC Cancer  2004;4:93

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