FPL 64176

  ( 5 citations )    
Product Datasheet
Catalog Number:1403
Chemical Name:2,5-Dimethyl-4-[2-(phenylmethyl)benzoyl]-1H-pyrrole-3-carboxylic acid methyl ester
Product Details
Citations (5)
Reviews
Biological Activity
Potent activator of L-type Ca2+ channels (EC50 = 16 nM). 40-fold more potent than Bay K 8644 (Cat. No. 1544) as a positive inotrope in guinea pig atria.
Technical Data
  • M.Wt:
    347.41
  • Formula:
    C22H21NO3
  • Solubility:
    Soluble to 25 mM in ethanol and to 50 mM in DMSO
  • Purity:
    >99
  • Storage:
    Store at RT
  • CAS No:
    120934-96-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for FPL 64176 include:

5 Citations: Showing 1 - 5
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  1. Calcium channel agonists protect against neuromuscular dysfunction in a genetic model of TDP-43 mutation in ALS.
    Authors: Armstrong and Drapeau
    Circ Heart Fail  2013;33:1741
  2. Characterization of Na+ and Ca2+ channels in zebrafish dorsal root ganglion neurons.
    Authors: Won Et al.
    PLoS One  2012;7:e42602
  3. Junctophilin-2 expression silencing causes cardiocyte hypertrophy and abnormal intracellular calcium-handling.
    Authors: Landstrom Et al.
    Endocr Relat Cancer  2011;4:214
  4. AKAP79/150 signal complexes in G-protein modulation of neuronal ion channels.
    Authors: Zhang Et al.
    J Neurosci  2011;31:7199
  5. Ionic currents in intimal cultured synoviocytes from the rabbit.
    Authors: Large Et al.
    Am J Physiol Cell Physiol  2010;299:C1180

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