Catalog Number: 1403
Chemical Name: 2,5-Dimethyl-4-[2-(phenylmethyl)benzoyl]-1H-pyrrole-3-carboxylic acid methyl ester
Biological Activity
Potent activator of L-type Ca2+ channels (EC50 = 16 nM). 40-fold more potent than Bay K 8644 (Cat. No. 1544) as a positive inotrope in guinea pig atria.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 25 mM in ethanol and to 50 mM in DMSO
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Discovery and synthesis of methyl 2,5-dimethyl-4-[2-(phenylmethyl)benzoyl]-1H-pyrrole-3-carboxylate (FPL 64176) and analogues: the first examples of a new class of calcium channel activator.
    Baxter et al.
    J.Med.Chem., 1993;36:2739
  2. Comparison of the in vitro and in vivo cardiovascular effects of two structurally distinct Ca++ channel activators, BAY K 8644 and FPL 64176.
    Rampe et al.
    J.Pharmacol.Exp.Ther., 1993;265:1125
  3. Pharmacological, radioligand binding, and electrophysiological characteristics of FPL 64176, a novel nondihydropyridine Ca2+ channel activator, in cardiac and vascular preparations.
    Zheng et al.
    Mol.Pharmacol., 1991;40:734

The citations listed below are publications that use Tocris products. Selected citations for FPL 64176 include:

Showing Results 1 - 4 of 4

  1. Calcium channel agonists protect against neuromuscular dysfunction in a genetic model of TDP-43 mutation in ALS.
    Authors: Armstrong and Drapeau
    Circ Heart Fail
  2. Junctophilin-2 expression silencing causes cardiocyte hypertrophy and abnormal intracellular calcium-handling.
    Authors: Landstrom Et al.
    Endocr Relat Cancer
  3. AKAP79/150 signal complexes in G-protein modulation of neuronal ion channels.
    Authors: Zhang Et al.
    J Neurosci
  4. Ionic currents in intimal cultured synoviocytes from the rabbit.
    Authors: Large Et al.
    Am J Physiol Cell Physiol
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