(±)-Bay K 8644

Tocris Bioscience | Catalog # 1544

CaV1.x activator
Tocris Bioscience

Key Product Details

Description

CaV1.x activator
View all Cav1.x Channel Activators »

Product Description

(±)-Bay K 8644 is a L-type Ca2+ channel activator (EC50 = 17.3 nM). Has positive inotropic, vasoconstrictive and behavioral effects in vivo. In combination with BIX-01294 (Cat. No. 3364), helps generate induced pluripotent stem cells (iPSCs) from mouse embryonic fibroblasts (MEFs). Inhibits autophagy.

(S)-(-)-Enantiomer and (R)-(+)-Enantiomer also available.

Product Specifications for (±)-Bay K 8644

Molecular Weight

356.30

Formula

C16H15F3N2O4

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid, methyl ester

CAS Number

71145-03-4

PubChem ID

2303

InChI Key

ZFLWDHHVRRZMEI-UHFFFAOYSA-N

SMILES

COC(=O)C1=C(C)NC(C)=C(C1C1=CC=CC=C1C(F)(F)F)[N+]([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 35.63 100
Ethanol 35.63 100

Preparing Stock Solutions for (±)-Bay K 8644

The following data is based on the product molecular weight 356.30.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.81 mL 14.03 mL 28.07 mL
5 mM 0.56 mL 2.81 mL 5.61 mL
10 mM 0.28 mL 1.40 mL 2.81 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 70 publications citing the usage of this product.

Product Documents for (±)-Bay K 8644

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for (±)-Bay K 8644

For research use only

Related Research Areas

Ion Channels and Regulators

Citations for (±)-Bay K 8644

Customer Reviews for (±)-Bay K 8644 (1)

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  • The pharmacological inhibitors for electrophysiology assay
    Name: Anonymous
    Species: skate
    Assay Type: In Vitro
    Verified Customer | Posted 02/28/2020
    The following concentrations we were used:1 μM Bay K, 10 μM nifedipine, 10 μM nimodipine, 300 nM omega -agatoxin, 1 μM omega -conotoxin, 5 μM mibefradil, 1 μM tetrodotoxin, 1 μM charybdotoxin, 100 nM iberiotoxin, 10 μM NS11021.
    (±)-Bay K 8644 1544

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