FPS ZM1

Tocris Bioscience | Catalog # 6237

High affinity antagonist of RAGE
Tocris Bioscience

Key Product Details

Description

High affinity antagonist of RAGE
View all NFkB/IkB Inhibitors »

Product Description

FPS ZM1 is a high affinity antagonist of the receptor for advanced glycation end products (RAGE) (Ki = 25 nM). Blocks Aβ binding to the V domain of RAGE and inhibits Aβ40- and Aβ42-induced cellular stress in RAGE-expressing cells in vitro and in the mouse brain in vivo. Blocks β-secretase activity, Aβ production, microglia activation and neuroinflammation in vivo. BBB permeable.

Product Specifications for FPS ZM1

Molecular Weight

327.85

Formula

C20H22ClNO

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

4-Chloro-N-cyclohexyl-N-(phenylmethyl)benzamide

CAS Number

945714-67-0

PubChem ID

24752728

InChI Key

XDFKWGIBQMHSOH-UHFFFAOYSA-N

SMILES

ClC1=CC=C(C(N(C2CCCCC2)CC3=CC=CC=C3)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 32.78 100
Ethanol 32.78 100

Preparing Stock Solutions for FPS ZM1

The following data is based on the product molecular weight 327.85.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.05 mL 15.25 mL 30.50 mL
5 mM 0.61 mL 3.05 mL 6.10 mL
10 mM 0.31 mL 1.53 mL 3.05 mL
50 mM 0.06 mL 0.31 mL 0.61 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 16 publications citing the usage of this product.

Product Documents for FPS ZM1

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for FPS ZM1

For research use only

Customer Reviews for FPS ZM1 (1)

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  • Good inhibitor
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vivo
    Cell Line/Tissue: phagocyte
    Verified Customer | Posted 06/06/2020
    DMSO dilution 10 μM

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