FPS ZM1

Catalog # Availability Size / Price Qty
6237/10
6237/50
FPS ZM1 | CAS No. 945714-67-0 | NFkB/IkB Inhibitors
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Description: High affinity antagonist of RAGE

Chemical Name: 4-Chloro-N-cyclohexyl-N-(phenylmethyl)benzamide

Purity: ≥99%

Product Details
Citations (1)
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Biological Activity

FPS ZM1 is a high affinity antagonist of the receptor for advanced glycation end products (RAGE) (Ki = 25 nM). Blocks Aβ binding to the V domain of RAGE and inhibits Aβ40- and Aβ42-induced cellular stress in RAGE-expressing cells in vitro and in the mouse brain in vivo. Blocks β-secretase activity, Aβ production, microglia activation and neuroinflammation in vivo. BBB permeable.

Technical Data

M.Wt:
327.85
Formula:
C20H22ClNO
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥99%
Storage:
Store at -20°C
CAS No:
945714-67-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citation for FPS ZM1

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