Catalog Number: 1507
Chemical Name: 1-[[4,5-bis(4-Methoxyphenyl)-2-thiazolyl]carbonyl]-4-methylpiperazine hydrochloride
Biological Activity
Selective cyclooxygenase-1 (COX-1) inhibitor (IC50 values are 0.028 and 65 μM for COX-1 and COX-2 respectively). Antiplatelet, analgesic and anti-inflammatory following oral administration in vivo.
Technical Data
  • M.Wt:
    459.99
  • Formula:
    C23H25N3O3S.HCl
  • Solubility:
    Soluble to 10 mM in water
  • Purity:
    >98%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    130717-51-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The anti-platelet actions of FR122047, a novel cyclooxygenase inhibitor.
    Dohi et al.
    Eur.J.Pharmacol., 1993;243:179
  2. The analgesic effect profile of FR122047, a selective cyclo-oxygenase-1 inhibitor, in chemical nociceptive models.
    Ochi et al.
    Eur.J.Pharmacol., 2000;391:49
  3. Differential effect of FR122047, a selective cyclo-oxygenase-1 inhibitor, in rat chronic models of arthritis.
    Ochi and Goto
    Br.J.Pharmacol., 2002;135:782
  4. Antiplatelet agents based on cyclooxygenase inhibition without ulcerogenesis. Evaluation and synthesis of 4,5-bis(4-methoxyphenyl)-2-substituted-thiazoles.
    Tanaka et al.
    J.Med.Chem., 1994;37:1189

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