FR 171113

Tocris Bioscience | Catalog # 3643

PAR1 antagonist
Tocris Bioscience

Key Product Details

Description

PAR1 antagonist
View all Protease-Activated Receptor Antagonists »

Product Description

FR 171113 is a protease-activated receptor 1 (PAR1) antagonist. Exhibits potent antiplatelet activity in vitro; inhibits thrombin TRAP-6-induced platelet aggregation (IC50 = 2.5 μM) with no effect on coagulation time.

Product Specifications for FR 171113

Molecular Weight

469.73

Formula

C19H11Cl3N2O4S

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

2-[3-(4-Chlorophenyl)-2-[(2,4-dichlorobenzoyl)imino]-4-oxo-5-thiazolidinylidene]-acetic acid methyl ester

CAS Number

173904-50-2

PubChem ID

25015749

InChI Key

SDGLYCKTPKZBGI-DALCUZTNSA-N

SMILES

O=C(/N=C(N(C3=CC=C(Cl)C=C3)C2=O)\S/C2=C/C(OC)=O)C1=CC=C(Cl)C=C1Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 4.7 10

Preparing Stock Solutions for FR 171113

The following data is based on the product molecular weight 469.73.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.29 mL 106.44 mL 212.89 mL
0.5 mM 4.26 mL 21.29 mL 42.58 mL
1 mM 2.13 mL 10.64 mL 21.29 mL
5 mM 0.43 mL 2.13 mL 4.26 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 5 publications citing the usage of this product.

Product Documents for FR 171113

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for FR 171113

For research use only

Customer Reviews for FR 171113 (1)

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  • PAR1 antagonism not awesome - perhaps SCH compound a better choice
    Name: Andrew Randall
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: Brain Pericytes
    Verified Customer | Posted 10/17/2019
    Really could not get this to dissolve at 10 mM in DMSO as website suggests - probably goes in around 7 mM. As this is not a very potent antagonist you will need to have quite a bit of DMSO around to get even partial antagonism.
    To attempt to block TRAP6 mediated Ca2+ mobilization in human pericytes. Its lack of potency and low solubility means it was not especially effective even with sub-maximal agonist concentrations - some antagonism or slowing of response - but not the complete block I had hoped for even when pre-equilibrated prior to agonist activation. We will now save our pennies to try the more potent SCH PAR1 antag

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