Chemical Name: 2-[3-(4-Chlorophenyl)-2-[(2,4-dichlorobenzoyl)imino]-4-oxo-5-thiazolidinylidene]-acetic acid methyl ester
Biological ActivityFR 171113 is a protease-activated receptor 1 (PAR1) antagonist. Exhibits potent antiplatelet activity in vitro; inhibits thrombin TRAP-6-induced platelet aggregation (IC50 = 2.5 μM) with no effect on coagulation time.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
In vitro antiplatelet profile of FR171113, a novel non-peptide thrombin receptor antagonist.
Kato et al.
Inhibition of arterial thrombosis by a protease-activated receptor 1 antagonist, FR171113, in the guinea pig.
Kato et al.
Citation for FR 171113
The citations listed below are publications that use Tocris products. Selected citations for FR 171113 include:
1 Citation: Showing 1 - 1
Disruption of epithelial barrier by quorum-sensing N-3-(oxododecanoyl)-homoserine lactone is mediated by matrix metalloproteinases.
Authors: Eum Et al.
Am J Physiol Gastrointest Liver Physiol 2014;306:G992
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Reviews for FR 171113
Average Rating: 3 (Based on 1 Review)
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To attempt to block TRAP6 mediated Ca2+ mobilization in human pericytes. Its lack of potency and low solubility means it was not especially effective even with sub-maximal agonist concentrations - some antagonism or slowing of response - but not the complete block I had hoped for even when pre-equilibrated prior to agonist activation. We will now save our pennies to try the more potent SCH PAR1 antag