Catalog Number: 3643
Chemical Name: 2-[3-(4-Chlorophenyl)-2-[(2,4-dichlorobenzoyl)imino]-4-oxo-5-thiazolidinylidene]-acetic acid methyl ester
Biological Activity
Protease-activated receptor 1 (PAR1) antagonist. Exhibits potent antiplatelet activity in vitro; inhibits thrombin TRAP-6-induced platelet aggregation (IC50 = 2.5 μM) with no effect on coagulation time.
Technical Data
  • M.Wt:
    469.73
  • Formula:
    C19H11Cl3N2O4S
  • Solubility:
    Soluble to 10 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    173904-50-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. In vitro antiplatelet profile of FR171113, a novel non-peptide thrombin receptor antagonist.
    Kato et al.
    Eur.J.Pharmacol., 1999;384:197
  2. Inhibition of arterial thrombosis by a protease-activated receptor 1 antagonist, FR171113, in the guinea pig.
    Kato et al.
    Eur.J.Pharmacol., 2003;473:163

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