FR 171113

Catalog # Availability Size / Price Qty
3643/10
3643/50
FR 171113 | CAS No. 173904-50-2 | Protease-Activated Receptor Antagonists
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Description: PAR1 antagonist

Chemical Name: 2-[3-(4-Chlorophenyl)-2-[(2,4-dichlorobenzoyl)imino]-4-oxo-5-thiazolidinylidene]-acetic acid methyl ester

Purity: ≥98%

Product Details
Citations (1)
Supplemental Products
Reviews (1)

Biological Activity

Protease-activated receptor 1 (PAR1) antagonist. Exhibits potent antiplatelet activity in vitro; inhibits thrombin TRAP-6-induced platelet aggregation (IC50 = 2.5 μM) with no effect on coagulation time.

Technical Data

M.Wt:
469.73
Formula:
C19H11Cl3N2O4S
Solubility:
Soluble to 10 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
173904-50-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for FR 171113

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PAR1 antagonism not awesome - perhaps SCH compound a better choice
By Andrew Randall on 10/17/2019
Species: Human

To attempt to block TRAP6 mediated Ca2+ mobilization in human pericytes. Its lack of potency and low solubility means it was not especially effective even with sub-maximal agonist concentrations - some antagonism or slowing of response - but not the complete block I had hoped for even when pre-equilibrated prior to agonist activation. We will now save our pennies to try the more potent SCH PAR1 antag


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