FR 180204

  ( 9 citations )    
Product Datasheet
Catalog Number:3706
Chemical Name:5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ylamine
Product Details
Citations (9)
Reviews
Biological Activity
Selective ERK inhibitor (IC50 values are 0.14 and 0.31 μM for ERK2 and ERK1 respectively). Displays 30-fold selectivity for ERK over p38α (IC50 = 10 μM); displays no activity against human recombinant MEK1, MKK4, IKKα, PKCα, Src, Syc and PDGFα at concentrations less than 30 μM. Also inhibits TGFβ-induced AP-1 activation in Mv1Lu cells (IC50 = 3.1 μM).
Technical Data
  • M.Wt:
    327.34
  • Formula:
    C18H13N7
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98
  • Storage:
    Store at +4°C
  • CAS No:
    865362-74-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for FR 180204 include:

9 Citations: Showing 1 - 9
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  1. Neurogenin 3 is regulated by neurotrophic tyrosine kinase receptor type 2 (TRKB) signaling in the adult human exocrine pancreas
    Authors: Shamblott Et al.
    Cell Communication and Signaling  2016;14:23
  2. Neurogenin 3 is regulated by neurotrophic tyrosine kinase receptor type 2(TRKB) signaling in the adult human exocrine pancreas.
    Authors: Shamblott Et al.
    Cell Communication and Signaling  2016;14:23
  3. Inhibition of ERK1/2 down-regulates the Hippo/YAP signaling pathway in human NSCLC cells.
    Authors: You Et al.
    Oncotarget  2015;6:4357
  4. Terminal epidermal differentiation is regulated by the interaction of Fra-2/AP-1 with Ezh2 and ERK1/2.
    Authors: Wurm Et al.
    PLoS Biol  2015;29:144
  5. A novel MEK-ERK-AMPK signaling axis controls chemokine receptor CCR7-dependent survival in human mature dendritic cells.
    Authors: López-Cotarelo Et al.
    Proc Natl Acad Sci U S A  2015;290:827
  6. δ-Opioid receptors up-regulate excitatory amino acid transporters in mouse astrocytes.
    Authors: Liang Et al.
    Microvasc Res  2014;171:5417
  7. A unique inhibitor binding site in ERK1/2 is associated with slow binding kinetics.
    Authors: Chaikuad Et al.
    Nat Chem Biol  2014;10:853
  8. HIF1A reduces acute lung injury by optimizing carbohydrate metabolism in the alveolar epithelium.
    Authors: Eckle Et al.
    J Biol Chem  2013;11:e1001665
  9. Post-transcriptional regulation of placenta growth factor mRNA by hydrogen peroxide.
    Authors: Shaw and Lloyd
    Genes Dev  2012;84:155

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