Selective ERK inhibitor (IC50
values are 0.14 and 0.31 μ
M for ERK2 and ERK1 respectively). Displays 30-fold selectivity for ERK over p38α
= 10 μ
M); displays no activity against human recombinant MEK1, MKK4, IKKα
, Src, Syc and PDGFα
at concentrations less than 30 μ
M. Also inhibits TGFβ
-induced AP-1 activation in Mv1Lu cells (IC50
= 3.1 μ
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Signaling to Extracellular Signal-regulated Kinase from ErbB1 Kinase and Protein Kinase C.
Perrett et al.
J Biol Chem., 2013;19:288
Identification of a selective ERK inhibitor and structural determination of the inhibitor-ERK2 complex.
Ohori et al.
The citations listed below are publications that use Tocris products. Selected citations for FR 180204 include:
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