FTY 720

   
Product Datasheet
Catalog Number:6176
Alternate Names:Fingolimod, Gilenya
Chemical Name:2-Amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol hydrochloride
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Biological Activity
S1P receptor agonist; undergoes phosphorylation by sphingosine kinase 2, which then binds S1P1,3,4 and 5 receptors (EC50 values are 0.3 - 0.6 nM for S1P1, 4 and 5 and ~3 nM for S1P3). Immunosuppresant; sequesters lymphocytes in lymph nodes, reducing autoimmune response. Suppresses the development of EAE (an in vivo model of MS). Orally bioavailable and blood-brain barrier permeable.
Technical Data
  • M.Wt:
    343.93
  • Formula:
    C19H33NO2.HCl
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
    >99
  • Storage:
    Store at -20°C
  • CAS No:
    162359-56-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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VersaClone cDNA Plasmids
Description Application Cat# Citations Images  

Mouse S1P1/EDG-1 (NP_031927) VersaClone cDNA

RDC0053
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Mouse S1P3/EDG-3 (NP_034231) VersaClone cDNA

RDC0220
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Human S1P5/EDG-8 (NP_110387) VersaClone cDNA

RDC0056
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Mouse S1P2/EDG-5 (NP_034463) VersaClone cDNA

RDC0221
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Human S1P3/EDG-3 (CAA58744) VersaClone cDNA

RDC0316
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Mouse S1P5/EDG-8 (NP_444420) VersaClone cDNA

RDC0465
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Human S1P1/EDG-1 (NP_001391) VersaClone cDNA

RDC0052
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Human S1P2/EDG-5 (NP_004221) VersaClone cDNA

RDC0055
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Human S1P2/EDG-5 (AAC98919) VersaClone cDNA

RDC0054
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