FTY 720

Catalog # Availability Size / Price Qty
6176/10
6176/50
FTY 720 | CAS No. 162359-56-0 | Sphingosine-1-phosphate Receptor Agonists
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Description: Potent S1P receptor agonist; also immunosuppressant
Alternative Names: Fingolimod, Gilenya

Chemical Name: 2-Amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol hydrochloride

Purity: ≥99%

Product Details
Citations (2)
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Biological Activity

S1P receptor agonist; undergoes phosphorylation by sphingosine kinase 2, which then binds S1P1,3,4 and 5 receptors (EC50 values are 0.3 - 0.6 nM for S1P1, 4 and 5 and ~3 nM for S1P3). Immunosuppresant; sequesters lymphocytes in lymph nodes, reducing autoimmune response. Suppresses the development of EAE (an in vivo model of MS). Orally bioavailable and blood-brain barrier permeable.

Technical Data

M.Wt:
343.93
Formula:
C19H33NO2.HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at -20°C
CAS No:
162359-56-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for FTY 720

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