Catalog Number: 6176
Alternate Names: Fingolimod, Gilenya
Chemical Name: 2-Amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol hydrochloride
Biological Activity
S1P receptor agonist; undergoes phosphorylation by sphingosine kinase 2, which then binds S1P1,3,4 and 5 receptors (EC50 values are 0.3 - 0.6 nM for S1P1, 4 and 5 and ~3 nM for S1P3). Immunosuppresant; sequesters lymphocytes in lymph nodes, reducing autoimmune response. Suppresses the development of EAE (an in vivo model of MS). Orally bioavailable and blood-brain barrier permeable.
Technical Data
  • M.Wt:
    343.93
  • Formula:
    C19H33NO2.HCl
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at -20°C
  • CAS No:
    162359-56-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. ACS chemical neuroscience molecule spotlight on gilenya (fingolimod; FTY720).
    Hopkins et al.
    ACS Chem. Neurosci., 2011;2:116
  2. Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis.
    Brinkmann et al.
    Nat. Rev. Drug Discov., 2010;9:883
  3. The immunomodulator FTY720 has a direct cytoprotective effect in oligodendrocyte progenitors.
    Coelho et al.
    J.Pharmacol.Exp.Ther., 2007;323:626
  4. CD69 acts downstream of interferon-alpha/beta to inhibit S1P1 and lymphocyte egress from lymphoid organs.
    Shiow et al.
    Nature, 2006;440:540
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