S1P receptor agonist; undergoes phosphorylation by sphingosine kinase 2, which then binds S1P1
values are 0.3 - 0.6 nM for S1P1
and ~3 nM for S1P3
). Immunosuppresant; sequesters lymphocytes in lymph nodes, reducing autoimmune response. Suppresses the development of EAE (an in vivo
model of MS). Orally bioavailable and blood-brain barrier permeable.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
ACS chemical neuroscience molecule spotlight on gilenya (fingolimod; FTY720).
Hopkins et al.
ACS Chem. Neurosci., 2011;2:116
Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis.
Brinkmann et al.
Nat. Rev. Drug Discov., 2010;9:883
The immunomodulator FTY720 has a direct cytoprotective effect in oligodendrocyte progenitors.
Coelho et al.
CD69 acts downstream of interferon-alpha/beta to inhibit S1P1 and lymphocyte egress from lymphoid organs.
Shiow et al.