Chemical Name: 2-Amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol hydrochloride
Biological ActivityS1P receptor agonist; undergoes phosphorylation by sphingosine kinase 2, which then binds S1P1,3,4 and 5 receptors (EC50 values are 0.3 - 0.6 nM for S1P1, 4 and 5 and ~3 nM for S1P3). Immunosuppresant; sequesters lymphocytes in lymph nodes, reducing autoimmune response. Suppresses the development of EAE (an in vivo model of MS). Orally bioavailable and blood-brain barrier permeable.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis.
Brinkmann et al.
Nat. Rev. Drug Discov., 2010;9:883
The immunomodulator FTY720 has a direct cytoprotective effect in oligodendrocyte progenitors.
Coelho et al.
CD69 acts downstream of IF.-alpha/beta to inhibit S1P1 and lymphocyte egress from lymphoid organs.
Shiow et al.
ACS chemical neuroscience molecule spotlight on gil. (fingolimod; FTY720).
Hopkins et al.
ACS Chem. Neurosci., 2011;2:116
Citations for FTY 720
The citations listed below are publications that use Tocris products. Selected citations for FTY 720 include:
2 Citations: Showing 1 - 2
Cell sensing and decision-making in confinement: The role of TRPM7 in a tug of war between hydraulic pressure and cross-sectional area.
Authors: Zhao Et al.
Sci Adv 2019;5:eaaw7243
Directional Migration in Esophageal Squamous Cell Carcinoma (ESCC) is Epigenetically Regulated by SET Nuclear Oncogene, a Member of the Inhibitor of Histone Acetyltransferase Complex.
Authors: Yuan Et al.
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
VersaClone cDNA Plasmids
Reviews for FTY 720
There are currently no reviews for this product. Be the first to review FTY 720 and earn rewards!
Have you used FTY 720?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image