Chemical Name:2-Amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol hydrochloride
Biological Activity S1P receptor agonist; undergoes phosphorylation by sphingosine kinase 2, which then binds S1P1,3,4 and 5 receptors (EC50 values are 0.3 - 0.6 nM for S1P1, 4 and 5 and ~3 nM for S1P3). Immunosuppresant; sequesters lymphocytes in lymph nodes, reducing autoimmune response. Suppresses the development of EAE (an in vivo model of MS). Orally bioavailable and blood-brain barrier permeable.
Soluble to 100 mM in water and to 100 mM in DMSO
Store at -20°C
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