FTY 720

Key Product Details

Product Description

FTY 720 is an S1P receptor agonist; undergoes phosphorylation by sphingosine kinase 2, which then binds S1P₁,₃,₄ and ₅ receptors (EC₅₀ values are 0.3 - 0.6 nM for S1P₁, ₄ and ₅ and ~3 nM for S1P₃). Immunosuppressant; sequesters lymphocytes in lymph nodes, reducing autoimmune response. Suppresses the development of EAE (an in vivo model of MS). Orally bioavailable and blood-brain barrier permeable.

Product Specifications for FTY 720

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for FTY 720

The following data is based on the product molecular weight 343.93.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.91 mL	14.54 mL	29.08 mL
5 mM	0.58 mL	2.91 mL	5.82 mL
10 mM	0.29 mL	1.45 mL	2.91 mL
50 mM	0.06 mL	0.29 mL	0.58 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 30 publications citing the usage of this product.

• Shiow CD69 acts downstream of IF.-alpha/beta to inhibit S1P₁ and lymphocyte egress from lymphoid organs. Nature 2006 PMID: 16525420
• Brinkmann Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis. Nat. Rev. Drug Discov. 2010 PMID: 21031003
• Coelho The immunomodulator FTY720 has a direct cytoprotective effect in oligodendrocyte progenitors. J.Pharmacol.Exp.Ther. 2007 PMID: 17726159
• Hopkins ACS chemical neuroscience molecule spotlight on gil. (fingolimod; FTY720). ACS Chem. Neurosci. 2011 PMID: 22778861

Product Documents for FTY 720