Chemical Name: 2-Amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol hydrochloride
Biological ActivityFTY 720 is a S1P receptor agonist; undergoes phosphorylation by sphingosine kinase 2, which then binds S1P1,3,4 and 5 receptors (EC50 values are 0.3 - 0.6 nM for S1P1, 4 and 5 and ~3 nM for S1P3). Immunosuppresant; sequesters lymphocytes in lymph nodes, reducing autoimmune response. Suppresses the development of EAE (an in vivo model of MS). Orally bioavailable and blood-brain barrier permeable.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis.
Brinkmann et al.
Nat. Rev. Drug Discov., 2010;9:883
The immunomodulator FTY720 has a direct cytoprotective effect in oligodendrocyte progenitors.
Coelho et al.
CD69 acts downstream of IF.-alpha/beta to inhibit S1P1 and lymphocyte egress from lymphoid organs.
Shiow et al.
ACS chemical neuroscience molecule spotlight on gil. (fingolimod; FTY720).
Hopkins et al.
ACS Chem. Neurosci., 2011;2:116
Citations for FTY 720
The citations listed below are publications that use Tocris products. Selected citations for FTY 720 include:
2 Citations: Showing 1 - 2
Cell sensing and decision-making in confinement: The role of TRPM7 in a tug of war between hydraulic pressure and cross-sectional area.
Authors: Zhao Et al.
Sci Adv 2019;5:eaaw7243
Directional Migration in Esophageal Squamous Cell Carcinoma (ESCC) is Epigenetically Regulated by SET Nuclear Oncogene, a Member of the Inhibitor of Histone Acetyltransferase Complex.
Authors: Yuan Et al.
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