Catalog Number: 4759
Chemical Name: (±)-(3aR*,4S*,9bS*)-4-(6-Bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-8-(1-methylethyl)-3H-cyclopenta[c]quinoline
Biological Activity
Antagonist of GPER; selectively inhibits estrogen-mediated activation of PI3-K by GPER, but not by ERα. Also inhibits estrogen-mediated calcium mobilization (IC50 = 112 nM). Analog of G-1 (Cat. No. 3577).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The G-protein-coupled estrogen receptor GPER in health and disease.
    Prossnitz and Barton
    Nat.Rev.Endocrinol., 2011;7:715
  2. Identification of a GPER/GPR30 antagonist with improved estrogen receptor counterselectivity.
    Dennis et al.
    J.Steroid Biochem.Mol.Biol., 2011;127:358
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