Home / Estrogen and Related Receptor Antagonists / G-36

G-36

4759 1 Citation Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4759/10
4759/50
G-36 | CAS No. 1392487-51-2 | Estrogen and Related Receptor Antagonists
1 Image
Description: Selective GPER antagonist

Chemical Name: (±)-(3aR*,4S*,9bS*)-4-(6-Bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-8-(1-methylethyl)-3H-cyclopenta[c]quinoline

Purity: ≥99%

Product Details
Citations (1)
Supplemental Products
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Antagonist of GPER; selectively inhibits estrogen-mediated activation of PI3-K by GPER, but not by ERα. Also inhibits estrogen-mediated calcium mobilization (IC50 = 112 nM). Structural analog of G-1 (Cat. No. 3577).

Technical Data

M.Wt:
412.33
Formula:
C22H22BrNO2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at -20°C
CAS No:
1392487-51-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. The G-protein-coupled estrogen receptor GPER in health and disease.
    Prossnitz and Barton
    Nat.Rev.Endocrinol., 2011;7:715
  2. Identification of a GPER/GPR30 antagonist with improved estrogen receptor counterselectivity.
    Dennis et al.
    J.Steroid Biochem.Mol.Biol., 2011;127:358

Product Datasheets

COA view current batch
Or select another batch:
SDS
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Citation for G-36

The citations listed below are publications that use Tocris products. Selected citations for G-36 include:

1 Citation: Showing 1 - 1

  1. Distal Dendritic Enrichment of HCN1 Channels in Hippocampal CA1 Is Promoted by Estrogen, but Does Not Require Reelin.
    Authors: Meseke Et al.
    Eneuro  2018;5

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

VersaClone cDNA Plasmids

Human GPER/GPR30 (NP_001496) VersaClone cDNA

RDC0352

Mouse GPER/GPR30 (NP_084047) VersaClone cDNA

RDC0390

Reviews for G-36

There are currently no reviews for this product. Be the first to review G-36 and earn rewards!

Have you used G-36?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.