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G-36

4759 1 Citation Datasheet / COA / SDS
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4759/10
4759/50
Estrogen and Related Receptor Antagonists Small Molecule
1 Image
Description: Selective GPER antagonist

Chemical Name: (±)-(3aR*,4S*,9bS*)-4-(6-Bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-8-(1-methylethyl)-3H-cyclopenta[c]quinoline

Purity: ≥99%

Product Details
Citations (1)
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Biological Activity

Antagonist of GPER; selectively inhibits estrogen-mediated activation of PI3-K by GPER, but not by ERα. Also inhibits estrogen-mediated calcium mobilization (IC50 = 112 nM). Structural analog of G-1 (Cat. No. 3577).

Technical Data

M.Wt:
412.33
Formula:
C22H22BrNO2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at -20°C
CAS No:
1392487-51-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. The G-protein-coupled estrogen receptor GPER in health and disease.
    Prossnitz and Barton
    Nat.Rev.Endocrinol., 2011;7:715
  2. Identification of a GPER/GPR30 antagonist with improved estrogen receptor counterselectivity.
    Dennis et al.
    J.Steroid Biochem.Mol.Biol., 2011;127:358

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Citation for G-36

The citations listed below are publications that use Tocris products. Selected citations for G-36 include:

1 Citation: Showing 1 - 1

  1. Distal Dendritic Enrichment of HCN1 Channels in Hippocampal CA1 Is Promoted by Estrogen, but Does Not Require Reelin.
    Authors: Meseke Et al.
    Eneuro  2018;5

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VersaClone cDNA Plasmids

Mouse GPER/GPR30 (NP_084047) VersaClone cDNA

RDC0390

Human GPER/GPR30 (NP_001496) VersaClone cDNA

RDC0352

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