Chemical Name: (±)-(3aR*,4S*,9bS*)-4-(6-Bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-8-(1-methylethyl)-3H-cyclopenta[c]quinoline
Biological ActivityG-36 is an antagonist of GPER; selectively inhibits estrogen-mediated activation of PI3-K by GPER, but not by ERα. Also inhibits estrogen-mediated calcium mobilization (IC50 = 112 nM). Structural analog of G-1 (Cat. No. 3577).
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Tocris products are intended for laboratory research use only, unless stated otherwise.
The G-protein-coupled estrogen receptor GPER in health and disease.
Prossnitz and Barton
Identification of a GPER/GPR30 antagonist with improved estrogen receptor counterselectivity.
Dennis et al.
J.Steroid Biochem.Mol.Biol., 2011;127:358
Citation for G-36
The citations listed below are publications that use Tocris products. Selected citations for G-36 include:
1 Citation: Showing 1 - 1
Distal Dendritic Enrichment of HCN1 Channels in Hippocampal CA1 Is Promoted by Estrogen, but Does Not Require Reelin.
Authors: Meseke Et al.
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