GA3-AM

Catalog # Availability Size / Price Qty
5407/50
5407/10
GA3-AM | CAS No. 1373154-68-7 | Protein Dimerizers
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Description: Gibberellin-analog (GA3) chemical dimerizer; cell permeable

Chemical Name: (1S,2S,4aR,4bR,7S,9aS,10S,10aR)-1,2,4b,5,6,7,8,9,10,10a-Decahydro-2,7-dihydroxy-1-methyl-8-methylene-13-oxo-4a,1-(epoxymethano)-7,9a-methanobenz[a]azulene-10-acetic acid (acetyloxy)methyl ester

Purity: ≥90%

Product Details
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Biological Activity

GA3-AM is a Gibberellin-analog (GA3) chemical dimerizer; induces rapid dimerization of GAIs and GID1. GA3-AM crosses the plasma membrane, is cleaved by cytosolic esterase releasing GA3, which then binds GID1- this complex then in turn forms a complex with GAI; this system works on a timescale of seconds (EC50 = 310 nM). GA3 and rapamycin (Cat. No. 1292) chemically inducible dimerization systems are orthogonal. Cell permeable.

Technical Data

M.Wt:
418.44
Formula:
C22H26O8
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥90%
Storage:
Store at -20°C
CAS No:
1373154-68-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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