GA3-AM

Name: GA3-AM
Brand: Tocris Bioscience
SKU: 5407

Tocris Bioscience | Catalog # 5407

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Citations (13)

Product Documents

Gibberellin-analog (GA3) chemical dimerizer; cell permeable

Discontinued Product

5407 has been discontinued. View all Protein Dimerizers products.

Product Description
Product Specifications
Solubility
Preparing Stock Solutions
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Gibberellin-analog (GA3) chemical dimerizer; cell permeable

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Product Description

GA3-AM is a Gibberellin-analog (GA₃) chemical dimerizer; induces rapid dimerization of GAIs and GID1. GA₃-AM crosses the plasma membrane, is cleaved by cytosolic esterase releasing GA₃, which then binds GID1- this complex then in turn forms a complex with GAI; this system works on a timescale of seconds (EC₅₀ = 310 nM). GA₃ and rapamycin (Cat. No. 1292) chemically inducible dimerization systems are orthogonal. Cell permeable.

Product Specifications for GA3-AM

Molecular Weight

418.44

Formula

C₂₂H₂₆O₈

Storage

Store at -20°C

Purity

≥90% (HPLC)

Chemical Name

(1S,2S,4aR,4bR,7S,9aS,10S,10aR)-1,2,4b,5,6,7,8,9,10,10a-Decahydro-2,7-dihydroxy-1-methyl-8-methylene-13-oxo-4a,1-(epoxymethano)-7,9a-methanobenz[a]azulene-10-acetic acid (acetyloxy)methyl ester

CAS Number

1373154-68-7

PubChem ID

56835187

InChI Key

IVIYFJSPDLOPEX-SEWSRMJOSA-N

SMILES

[H][C@@]12[C@@](C[C@@]3(O)CC2)(CC3=C)[C@@H](C(OCOC(C)=O)=O)[C@]4([H])[C@@]5(C)[C@@H](O)C=C[C@]41OC5=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	41.84	100
	Ethanol	41.84	100

Preparing Stock Solutions for GA3-AM

The following data is based on the product molecular weight 418.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.39 mL	11.95 mL	23.90 mL
5 mM	0.48 mL	2.39 mL	4.78 mL
10 mM	0.24 mL	1.19 mL	2.39 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 13 publications citing the usage of this product.

Miyamoto Rapid and orthogonal logic gating with a gibberellin-induced dimerization system Nat.Chem.Biol. 2012 PMID: 22446836
Lin Rapidly reversible manipulation of molecular activities using dual chemical dimerizers Angew.Chem.Int.Ed.Engl. 2013 PMID: 23649661

Product Documents for GA3-AM

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Download SDS

Product Specific Notices for GA3-AM

For research use only

Citations for GA3-AM

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