GABA Transporter 2 Antibody

Novus Biologicals | Catalog # NB100-1872

Novus Biologicals
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Cited:

Human, Rat

Applications

Validated:

Western Blot, ELISA, Flow Cytometry

Cited:

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG
View all GABA Transporter 2 Primary Antibodies »

Product Specifications

Immunogen

A 15 residue C-teminal domain synthetic peptide (Rat).

Reactivity Notes

Cross-reacts with Human, Mouse, Rat and Chicken (see review). Not yet tested in other species.

Specificity

Reacts specifically with protein derived from CNS samples.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for GABA Transporter 2 Antibody

Western Blot: GABA Transporter 2 Antibody [NB100-1872]

Western Blot: GABA Transporter 2 Antibody [NB100-1872]

GABA-Transporter-2-Antibody-Western-Blot-NB100-1872-img0003.jpg
Western Blot: GABA Transporter 2 Antibody [NB100-1872]

Western Blot: GABA Transporter 2 Antibody [NB100-1872]

Western Blot: GABA Transporter 2 Antibody [NB100-1872] - Analysis of GABA 2 levels in 20 ug of young and old RPE cell lysates. [PMID: 22701690]
GABA Transporter 2 Antibody

Western Blot: GABA Transporter 2 Antibody [NB100-1872] -

Levels of identified proteins in RPE lysates.Both young (2 months) and old (24 months) RPE cells were harvested, lysed. 20 µg of protein of each sample was separated on a 4–20% SDS gel, transferred to PVDF membranes and probed with antibodies specified followed by ECF detection of immunoreactivity. Decreased content of DDAH I and DPPX were observed in old RPE lysates. Contrary, increased content of GABA2, CD46, DJ-1, cathepsin D, EBP50 and ezrin were detected in old RPE lysates.

Applications for GABA Transporter 2 Antibody

Application
Recommended Usage

Western Blot

1/200-1/5000

Flow Cytometry Panel Builder

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Flow Cytometry

Formulation, Preparation, and Storage

Purification

Unpurified

Reconstitution

Lyophilized powder, reconstituted in distilled water.

Formulation

Antiserum

Preservative

No Preservative

Concentration

This product is unpurified. The exact concentration of antibody is not quantifiable.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Calculators

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: GABA Transporter 2

GABA is a major inhibitory neurotransmitter and the GABAergic transmission is terminated by the rapid Na+/Cl-dependent uptake of through GABA transporters. There are multiple subtypes of GABA transporters (GAT1, GAT2, GAT3; and betaine GABA transporter (BGT-1). There is 50percent homology between each subtypes. GAT1 and GAT3 have been detected in various parts of the brain while GAT2 is found in many tissues. It appears that GAT1 and GAT3 are involved in distinct GABAergic transmission while GAT2 may be important in non-neural functions. GAT2 is a gamma-amino butyric acid (GABA) transporter. It is a 602 amino acid (85kDa) transmembrane protein

Long Name

Sodium- and chloride-dependent GABA transporter 2

Alternate Names

GAT-2, GAT2, SLC6A13

Entrez Gene IDs

171163 (Rat)

Gene Symbol

SLC6A13

UniProt

P31646 (Rat)

Additional GABA Transporter 2 Products

Product Documents for GABA Transporter 2 Antibody

Certificate of Analysis

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Product Specific Notices for GABA Transporter 2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Citations for GABA Transporter 2 Antibody

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Protocols

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FAQs

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