Catalog # Availability Size / Price Qty
Gallein | CAS No. 2103-64-2 | G Protein (Heterotrimeric) Inhibitors
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Description: Inhibitor of Gβ/γ signaling

Chemical Name: 3',4',5',6'-Tetrahydroxyspiro[isobenzofuran-1(3H),9'-(9H)xanthen]-3-one

Purity: ≥97%

Product Details
Citations (21)

Biological Activity

Gallein is an inhibitor of G protein βγ subunit-dependent signaling. Blocks PI 3-kinase and Rac1 activation in HL60 cells and chemotaxis in HL60 differentiated cells.

Technical Data

Soluble to 75 mM in DMSO and to 10 mM in ethanol
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Gallein

The citations listed below are publications that use Tocris products. Selected citations for Gallein include:

21 Citations: Showing 1 - 10

  1. Protumoral bone marrow-derived cells migrate via Gβγ-dependent signaling pathways and exhibit a complex repertoire of RhoGEFs.
    Authors: Cervantes-Villagrana Et al.
    J Cell Commun Signal  2019;13:179
  2. Ethanolic Extract of Folium Sennae Mediates the Glucose Uptake of L6 Cells by GLUT4 and Ca2.
    Authors: Zhao Et al.
    Molecules  2018;23
  3. Biased OXTergic Modulation of Midbrain DA Systems.
    Authors: Xiao Et al.
    Neuron  2017;95:368
  4. Pharmacological and Activated Fibroblast Targeting of Gβγ-GRK2 After Myocardial Ischemia Attenuates Heart Failure Progression.
    Authors: Travers Et al.
    J Am Coll Cardiol  2017;70:958
  5. Structural and pharmacological basis for the induction of mitochondrial biogenesis by formo. but not clenbu.
    Authors: Cameron
    Sci Rep  2017;7(1):10578
  6. Activation of odorant receptor in colorectal cancer cells leads to inhibition of cell proliferation and apoptosis.
    Authors: Weber
    PLoS One  2017;12(3):e0172491
  7. Activation of Adenosine 2A receptor inhibits neutrophil apoptosis in an autophagy-dependent manner in mice with systemic inflammatory response syndrome.
    Authors: Liu Et al.
    Scientific Reports  2016;6:33614
  8. The β2-adrenoceptor activates a positive cAMP-calcium feedforward loop to drive breast cancer cell invasion.
    Authors: Pon Et al.
    FASEB J  2016;30:1144
  9. Tryptophan hydroxylase 1 and 5-HT7 receptor preferentially expressed in triple-negative breast cancer promote cancer progression through autocrine serotonin signaling.
    Authors: Gautam Et al.
    Mol Cancer  2016;15:75
  10. A novel MEK-ERK-AMPK signaling axis controls chemokine receptor CCR7-dependent survival in human mature dendritic cells.
    Authors: López-Cotarelo Et al.
    Inflamm Res  2015;290:827
  11. Albumin-associated free fatty acids induce macropinocytosis in podocytes.
    Authors: Chung Et al.
    J Clin Invest  2015;125:2307
  12. G-protein βγ subunits are positive regulators of Kv7.4 and native vascular Kv7 channel activity.
    Authors: Stott Et al.
    Proc Natl Acad Sci U S A  2015;112:6497
  13. Promotion of cancer cell invasiveness and metastasis emergence caused by olfactory receptor stimulation.
    Authors: Sanz Et al.
    PLoS One  2014;9:e85110
  14. Bitter taste receptor agonists elicit G-protein-dependent negative inotropy in the murine heart.
    Authors: Foster Et al.
    FASEB J  2014;28:4497
  15. Melanopsin mediates light-dependent relaxation in blood vessels.
    Authors: Sikka Et al.
    J Biol Chem  2014;111:17977
  16. Superantigens are critical for Staphylococcus aureus Infective endocarditis, sepsis, and acute kidney injury.
    Authors: Salgado-Pabón Et al.
    MBio  2013;4
  17. DA D2 receptor activation leads to an up-regulation of glial cell line-derived neurotrophic factor via Gβγ-Erk1/2-dependent induction of Zif268.
    Authors: Ahmadiantehrani and Ron
    J Neurochem  2013;
  18. A disintegrin and metalloproteinase 17 (ADAM17) and epidermal growth factor receptor (EGFR) signaling drive the epithelial response to Staphylococcus aureus toxic shock syndrome toxin-1 (TSST-1).
    Authors: Breshears Et al.
    J Biol Chem  2012;287:32578
  19. G-protein βγ subunits in vasorelaxing and anti-endothelinergic effects of calcitonin gene-related peptide.
    Authors: Meens Et al.
    Br J Pharmacol  2012;166:297
  20. Phosphoinositide 3-kinase-dependent antagonism in mammalian olfactory receptor neurons.
    Authors: Ukhanov Et al.
    J Neurosci  2011;31:273
  21. β1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons.
    Authors: Meitzen Et al.
    J Neurochem  2011;116:984


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