Catalog Number: 3090
Chemical Name: 3',4',5',6'-Tetrahydroxyspiro[isobenzofuran-1(3H),9'-(9H)xanthen]-3-one
Biological Activity
Inhibitor of G protein βγ subunit-dependent signaling. Blocks PI 3-kinase and Rac1 activation in HL60 cells and chemotaxis in HL60 differentiated cells.
Technical Data
  • M.Wt:
    364.31
  • Formula:
    C20H12O7
  • Solubility:
    Soluble to 75 mM in DMSO and to 10 mM in ethanol
  • Purity:
    >97%
  • Storage:
    Store at -20°C
  • CAS No:
    2103-64-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Small molecule disruption of G protein βγ subunit signaling inhibits neutrophil chemotaxis and inflammation.
    Lehmann et al.
    Mol.Pharmacol., 2008;73:410
  2. Phosphoinositide 3-kinase-dependent antagonism in mammalian olfactory receptor neurons.
    Ukhanov et al.
    J.Neurosci., 2011;31:273
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Gallein include:

11 Citations: Showing 1 - 10
Filter your results:

  1. Activation of odorant receptor in colorectal cancer cells leads to inhibition of cell proliferation and apoptosis.
    Authors: Weber
    PLoS One 2017;12(3):e0172491
  2. Activation of Adenosine 2A receptor inhibits neutrophil apoptosis in an autophagy-dependent manner in mice with systemic inflammatory response syndrome.
    Authors: Liu Et al.
    Scientific Reports 2016;6:33614
  3. A novel MEK-ERK-AMPK signaling axis controls chemokine receptor CCR7-dependent survival in human mature dendritic cells.
    Authors: López-Cotarelo Et al.
    Inflamm Res 2015;290:827
  4. Albumin-associated free fatty acids induce macropinocytosis in podocytes.
    Authors: Chung Et al.
    J Clin Invest 2015;125:2307
  5. G-protein βγ subunits are positive regulators of Kv7.4 and native vascular Kv7 channel activity.
    Authors: Stott Et al.
    Proc Natl Acad Sci U S A 2015;112:6497
  6. Promotion of cancer cell invasiveness and metastasis emergence caused by olfactory receptor stimulation.
    Authors: Sanz Et al.
    PLoS One 2014;9:e85110
  7. Melanopsin mediates light-dependent relaxation in blood vessels.
    Authors: Sikka Et al.
    J Biol Chem 2014;111:17977
  8. Superantigens are critical for Staphylococcus aureus Infective endocarditis, sepsis, and acute kidney injury.
    Authors: Salgado-Pabón Et al.
    MBio 2013;4
  9. Dopamine D2 receptor activation leads to an up-regulation of glial cell line-derived neurotrophic factor via Gβγ-Erk1/2-dependent induction of Zif268.
    Authors: Ahmadiantehrani and Ron
    J Neurochem 2013;
  10. A disintegrin and metalloproteinase 17 (ADAM17) and epidermal growth factor receptor (EGFR) signaling drive the epithelial response to Staphylococcus aureus toxic shock syndrome toxin-1 (TSST-1).
    Authors: Breshears Et al.
    J Biol Chem 2012;287:32578
  11. β1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons.
    Authors: Meitzen Et al.
    J Neurochem 2011;116:984
Expand to show all 11 Citations

Have you used Gallein?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Note:

Contact Information

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee

or select another batch: 

Feedback

Customer Information