Catalog Number: 3090
Chemical Name: 3',4',5',6'-Tetrahydroxyspiro[isobenzofuran-1(3H),9'-(9H)xanthen]-3-one
Biological Activity
Inhibitor of G protein βγ subunit-dependent signaling. Blocks PI 3-kinase and Rac1 activation in HL60 cells and chemotaxis in HL60 differentiated cells.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 75 mM in DMSO and to 10 mM in ethanol
  • Purity:
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Small molecule disruption of G protein βγ subunit signaling inhibits neutrophil chemotaxis and inflammation.
    Lehmann et al.
    Mol.Pharmacol., 2008;73:410
  2. Phosphoinositide 3-kinase-dependent antagonism in mammalian olfactory receptor neurons.
    Ukhanov et al.
    J.Neurosci., 2011;31:273

The citations listed below are publications that use Tocris products. Selected citations for Gallein include:

Showing Results 1 - 10 of 10

  1. Activation of Adenosine 2A receptor inhibits neutrophil apoptosis in an autophagy-dependent manner in mice with systemic inflammatory response syndrome.
    Authors: Liu Et al.
    Scientific Reports
  2. A novel MEK-ERK-AMPK signaling axis controls chemokine receptor CCR7-dependent survival in human mature dendritic cells.
    Authors: López-Cotarelo Et al.
    Inflamm Res
  3. Albumin-associated free fatty acids induce macropinocytosis in podocytes.
    Authors: Chung Et al.
    J Clin Invest
  4. G-protein βγ subunits are positive regulators of Kv7.4 and native vascular Kv7 channel activity.
    Authors: Stott Et al.
    Proc Natl Acad Sci U S A
  5. Promotion of cancer cell invasiveness and metastasis emergence caused by olfactory receptor stimulation.
    Authors: Sanz Et al.
    PLoS One
  6. Melanopsin mediates light-dependent relaxation in blood vessels.
    Authors: Sikka Et al.
    J Biol Chem
  7. Dopamine D2 receptor activation leads to an up-regulation of glial cell line-derived neurotrophic factor via Gβγ-Erk1/2-dependent induction of Zif268.
    Authors: Ahmadiantehrani and Ron
    J Neurochem
  8. Superantigens are critical for Staphylococcus aureus Infective endocarditis, sepsis, and acute kidney injury.
    Authors: Salgado-Pabón Et al.
  9. A disintegrin and metalloproteinase 17 (ADAM17) and epidermal growth factor receptor (EGFR) signaling drive the epithelial response to Staphylococcus aureus toxic shock syndrome toxin-1 (TSST-1).
    Authors: Breshears Et al.
    J Biol Chem
  10. β1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons.
    Authors: Meitzen Et al.
    J Neurochem
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

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