Gallein

  ( 16 citations ) ( 1 Review )    
Product Datasheet
Catalog Number:3090
Chemical Name:3',4',5',6'-Tetrahydroxyspiro[isobenzofuran-1(3H),9'-(9H)xanthen]-3-one
Product Details
Citations (16)
Reviews
Biological Activity
Inhibitor of G protein βγ subunit-dependent signaling. Blocks PI 3-kinase and Rac1 activation in HL60 cells and chemotaxis in HL60 differentiated cells.
Technical Data
  • M.Wt:
    364.31
  • Formula:
    C20H12O7
  • Solubility:
    Soluble to 75 mM in DMSO and to 10 mM in ethanol
  • Purity:
    >97
  • Storage:
    Store at -20°C
  • CAS No:
    2103-64-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Gallein include:

16 Citations: Showing 1 - 10
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  1. Structural and pharmacological basis for the induction of mitochondrial biogenesis by formoterol but not clenbuterol.
    Authors: Cameron
    Sci Rep  2017;7(1):10578
  2. Activation of odorant receptor in colorectal cancer cells leads to inhibition of cell proliferation and apoptosis.
    Authors: Weber
    PLoS One  2017;12(3):e0172491
  3. Activation of Adenosine 2A receptor inhibits neutrophil apoptosis in an autophagy-dependent manner in mice with systemic inflammatory response syndrome.
    Authors: Liu Et al.
    Scientific Reports  2016;6:33614
  4. The β2-adrenoceptor activates a positive cAMP-calcium feedforward loop to drive breast cancer cell invasion.
    Authors: Pon Et al.
    FASEB J  2016;30:1144
  5. Tryptophan hydroxylase 1 and 5-HT7 receptor preferentially expressed in triple-negative breast cancer promote cancer progression through autocrine serotonin signaling.
    Authors: Gautam Et al.
    Mol Cancer  2016;15:75
  6. A novel MEK-ERK-AMPK signaling axis controls chemokine receptor CCR7-dependent survival in human mature dendritic cells.
    Authors: López-Cotarelo Et al.
    Inflamm Res  2015;290:827
  7. Albumin-associated free fatty acids induce macropinocytosis in podocytes.
    Authors: Chung Et al.
    J Clin Invest  2015;125:2307
  8. G-protein βγ subunits are positive regulators of Kv7.4 and native vascular Kv7 channel activity.
    Authors: Stott Et al.
    Proc Natl Acad Sci U S A  2015;112:6497
  9. Promotion of cancer cell invasiveness and metastasis emergence caused by olfactory receptor stimulation.
    Authors: Sanz Et al.
    PLoS One  2014;9:e85110
  10. Melanopsin mediates light-dependent relaxation in blood vessels.
    Authors: Sikka Et al.
    J Biol Chem  2014;111:17977
  11. Superantigens are critical for Staphylococcus aureus Infective endocarditis, sepsis, and acute kidney injury.
    Authors: Salgado-Pabón Et al.
    MBio  2013;4
  12. Dopamine D2 receptor activation leads to an up-regulation of glial cell line-derived neurotrophic factor via Gβγ-Erk1/2-dependent induction of Zif268.
    Authors: Ahmadiantehrani and Ron
    J Neurochem  2013;
  13. A disintegrin and metalloproteinase 17 (ADAM17) and epidermal growth factor receptor (EGFR) signaling drive the epithelial response to Staphylococcus aureus toxic shock syndrome toxin-1 (TSST-1).
    Authors: Breshears Et al.
    J Biol Chem  2012;287:32578
  14. G-protein βγ subunits in vasorelaxing and anti-endothelinergic effects of calcitonin gene-related peptide.
    Authors: Meens Et al.
    Br J Pharmacol  2012;166:297
  15. Phosphoinositide 3-kinase-dependent antagonism in mammalian olfactory receptor neurons.
    Authors: Ukhanov Et al.
    J Neurosci  2011;31:273
  16. β1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons.
    Authors: Meitzen Et al.
    J Neurochem  2011;116:984
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Average Rating: 4 (Based on 1 review)

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  Very Good
  Mouse Rocco Latorre 12/13/2017
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Summary

Species Mouse

Other Experimental Details

Other Experimental Details Gallein is not easy to dissolve in solution, to do that is better dissolve gallein in a small quantity of DMSO and then reach your final concentration using Saline. Total DMSO% in the final volume should be no more then 0.5%.

Please scroll the above reviews for more
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

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