Chemical Name: 3,8,9,10-Tetrahydroxypyrano[3,2-c]benzopyran-2,6-dione potassium salt
Biological ActivityGalloflavin is an inhibitor of human lactate dehydrogenase (LDH) (Ki values are 5.46 and 15.1 μM for LDH-A and LDH-B, respectively, in competition with pyruvate). Inhibits lactate production and decreases ATP synthesis in PLD/PRF/5 cells; thought to decrease cell viability via impairment of aerobic glycolysis.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Galloflavin (CAS 568-80-9): a novel inhibitor of lactate dehydrogenase.
Manerba et al.
Galloflavin prevents the binding of lactate dehydrogenase A to single stranded DNA and inhibits RNA synthesis in cultured cells.
Fiume et al.
Galloflavin, a new lactate dehydrogenase inhibitor, induces the death of human breast cancer cells with different glycolytic attitude by affecting distinct signaling pathways.
Farabegoli et al.
Citations for Galloflavin
The citations listed below are publications that use Tocris products. Selected citations for Galloflavin include:
2 Citations: Showing 1 - 2
Galloflavin Plus Metformin Treatment Impairs Pancreatic Cancer Cells.
Authors: Dietmar Et al.
Anticancer Res 2020;40:153-160
LKB1 loss links serine metabolism to DNA methylation and tumorigenesis.
Authors: Kottakis Et al.
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