GAP-43 [p Ser41] Antibody - Azide and BSA Free

Novus Biologicals | Catalog # NBP3-05419

Novus Biologicals
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Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

Azide and BSA Free
View all GAP-43 Primary Antibodies »

Product Specifications

Immunogen

A synthetic phosphorylated peptide around S41 of human GAP-43 (NP_002036.1). QASFR

Modification

p Ser41

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for GAP-43 [p Ser41] Antibody - Azide and BSA Free

GAP-43 [p Ser41] Antibody - Azide and BSA Free

Immunocytochemistry/ Immunofluorescence: GAP-43 [p Ser41] Antibody - Azide and BSA Free [NBP3-05419] -

Immunocytochemistry/ Immunofluorescence: GAP-43 [p Ser41] Antibody - Azide and BSA Free [NBP3-05419] - empty

Applications for GAP-43 [p Ser41] Antibody - Azide and BSA Free

Application
Recommended Usage

Western Blot

1:500 - 1:2000

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.3), 50% glycerol

Format

Azide and BSA Free

Preservative

0.01% Thimerosal

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: GAP-43

GAP43 (Growth associated protein 43) is a crucial component for regenerative response in the nervous system. GAP-43 is normally produced by neurons during developmental growth and axonal regeneration, but it is also expressed in specific regions of the normal adult nervous system. The protein is present at high levels in neuronal growth cones during development and axonal regeneration.

Heterozygous GAP3 knockout mice with GAP-43 levels reduced by one-half display significant memory impairments in cued conditioning, or on tests of nociceptive or auditory perception. Differentiating neurons that do not express GAP-43 show mislocalization of the centrosome and mitotic spindles, particularly in neurogenic cell divisions. Therefore, the neuronal precursor pool in the cerebellum fails to grow resulting in a cerebellum that is significantly smaller than normal. Total GAP-43 deletion is lethal within days of birth, demonstrating that GAP-43 is critical for the proper development of the mammalian CNS.

Long Name

Growth Associated Protein 43

Alternate Names

B-50, Basp2, GAP43, Neuromodulin

Gene Symbol

GAP43

Additional GAP-43 Products

Product Documents for GAP-43 [p Ser41] Antibody - Azide and BSA Free

Certificate of Analysis

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Product Specific Notices for GAP-43 [p Ser41] Antibody - Azide and BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

⚠ WARNING: This product can expose you to chemicals including Methotrexate, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

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