Gastrin I (human)
Purity: ≥95%
Biological Activity
Gastrin I (human) is an endogenous peptide produced in the stomach that acts as a selective CCK2 receptor agonist. Gastrin I stimulates gastric acid secretion and has a mitogenic effect on gastric cells. Gastrin I stimulates gastric epithelial cell proliferation and histamine secretion (EC50 values are 6.2 pM and 0.014 nM, respectively). Gastrin I is also used in the culture of stomach, intestine and pancreas organoids. For more information about using Gastrin I in the generation of gastric organoids see the Human Gastric Organoid Culture Protocol.Technical Data
(Modifications: X = Glp, Phe-17 = C-terminal amide)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
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Background References
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International union of pharmacology XXI. Structure, distribution, and functions of cholecystokinin receptors.
Noble et al.
Pharmacol.Rev., 1999;51:745 -
CCK1 and CCK2 receptors regulate gastric pepsinogen secretion.
Blandizzi et al.
Eur.J.Pharmacol., 1999;373:71 -
In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection.
Bartfeld et al.
Gastroenterology, 2015;148:126 -
SnapShot: Growing Organoids from Stem Cells.
Sato et al.
Cell, 2015;161:1700 -
Establishment of gastrointestinal epithelial organoids
Mahe et al.
Curr.Protoc. Mouse Biol., 2014;3:217
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Citations for Gastrin I (human)
The citations listed below are publications that use Tocris products. Selected citations for Gastrin I (human) include:
9 Citations: Showing 1 - 9
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Estrogen-related receptor alpha drives mitochondrial biogenesis and resistance to neoadjuvant chemoradiation in esophageal cancer.
Authors: Dings Et al.
Cell.Rep.Med. 2022;3:100802
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Optimized human intestinal organoid model reveals interleukin-22-dependency of paneth cell formation.
Authors: He Et al.
Cell Stem Cell 2022;29:1333
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Snake venom gland organoids.
Authors: Post Et al.
Cell 2020;180:233
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Immunoevolution of mouse pancreatic organoid isografts from preinvasive to metastatic disease.
Authors: Filippini Et al.
Sci Rep 2019;9:12286
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IKKα Kinase Regulates the DNA Damage Response and Drives Chemo-resistance in Cancer.
Authors: Colomer Et al.
Mol Cell 2019;75:669
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TP63-Mediated Enhancer Reprogramming Drives the Squamous Subtype of Pancreatic Ductal Adenocarcinoma.
Authors: Somerville Et al.
Cell Rep 2018;25:1741
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Enhancer Reprogramming Promotes Pancreatic Cancer Metastasis.
Authors: Roe Et al.
Cell 2017;170:875
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In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection.
Authors: Bartfeld Et al.
Front Cell Neurosci 2015;148:126
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In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection.
Authors: Bartfeld Et al.
Gastroenterology 2015;148:126
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Used to stimulate pancreatic acinar cells to secrete digestive enzymes in vitro
