Gastrin I (human)
Biological Activity
Gastrin I (human) is an endogenous peptide produced in the stomach that acts as a selective CCK2 receptor agonist. Stimulates gastric acid secretion. Also used in the culture of stomach organoids.Technical Data
(Modifications: X = Glp, Phe-17 = C-terminal amide)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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International union of pharmacology XXI. Structure, distribution, and functions of cholecystokinin receptors.
Noble et al.
Pharmacol.Rev., 1999;51:745 -
CCK1 and CCK2 receptors regulate gastric pepsinogen secretion.
Blandizzi et al.
Eur.J.Pharmacol., 1999;373:71 -
In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection.
Bartfeld et al.
Gastroenterology, 2015;148:126 -
SnapShot: Growing Organoids from Stem Cells.
Sato et al.
Cell, 2015;161:1700 -
Establishment of gastrointestinal epithelial organoids
Mahe et al.
Curr.Protoc. Mouse Biol., 2014;3:217
Product Datasheets
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Citations for Gastrin I (human)
The citations listed below are publications that use Tocris products. Selected citations for Gastrin I (human) include:
7 Citations: Showing 1 - 7
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Snake venom gland organoids.
Authors: Post Et al.
Cell 2020;180:233
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Immunoevolution of mouse pancreatic organoid isografts from preinvasive to metastatic disease.
Authors: Filippini Et al.
Sci Rep 2019;9:12286
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IKKα Kinase Regulates the DNA Damage Response and Drives Chemo-resistance in Cancer.
Authors: Colomer Et al.
Mol Cell 2019;75:669
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TP63-Mediated Enhancer Reprogramming Drives the Squamous Subtype of Pancreatic Ductal Adenocarcinoma.
Authors: Somerville Et al.
Cell Rep 2018;25:1741
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Enhancer Reprogramming Promotes Pancreatic Cancer Metastasis.
Authors: Roe Et al.
Cell 2017;170:875
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In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection.
Authors: Bartfeld Et al.
Front Cell Neurosci 2015;148:126
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In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection.
Authors: Bartfeld Et al.
Gastroenterology. 2015;148:126
FAQs
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Reviews for Gastrin I (human)
Average Rating: 5 (Based on 1 Review)
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Used to stimulate pancreatic acinar cells to secrete digestive enzymes in vitro
