Gavestinel

Catalog # Availability Size / Price Qty
2348/10
2348/50
Cat.No. 2348 - Gavestinel | C18H11Cl2N2O3Na | CAS No. 153436-38-5
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Description: Potent and selective glycine site antagonist; orally available and active in vivo
Alternative Names: GV 150526A

Chemical Name: 4,6-Dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propenyl]-1H-indole-2-carboxylic acid sodium salt

Purity: ≥98%

Product Details
Reviews

Biological Activity

Highly potent and selective non-competitive antagonist acting at the strychnine-insensitive glycine binding site of the NMDA receptor-channel complex (Kd = 0.8 nM). Displays > 1000-fold selectivity over NMDA, AMPA and kainate binding sites. Orally bioavailable and active in vivo.

Technical Data

M.Wt:
397.19
Formula:
C18H11Cl2N2O3Na
Solubility:
Soluble to 40 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
153436-38-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Additional Information

Licensing Caveats:
Sold with the permission of GlaxoSmithKline

Product Datasheets

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