GC 1

Key Product Details

Product Description

GC 1 is a thyromimetic; high affinity agonist at thyroid hormone receptor (TR) β and TRα receptors (K_D values are 67 and 440 pM respectively). Displays 5- and 100-fold greater potency than the endogenous agonist T₃ in vitro at TRα₁ and TRβ₁ receptors respectively. Promotes reverse cholesterol transport in chow- and fat-fed mice. Induces proliferation of hepatocytes and pancreatic acinar cells in rats independent of prior tissue injury.

Product Specifications for GC 1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for GC 1

The following data is based on the product molecular weight 328.40.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	6.09 mL	30.45 mL	60.90 mL
2.5 mM	1.22 mL	6.09 mL	12.18 mL
5 mM	0.61 mL	3.05 mL	6.09 mL
25 mM	0.12 mL	0.61 mL	1.22 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 22 publications citing the usage of this product.

• Johansson Selective thyroid receptor modulation by GC-1 reduces serum lipids and stimulates steps of reverse cholesterol transport in euthyroid mice. Proc.Natl.Acad.Sci. U S A 2005 PMID: 16006512
• Columbano The thyroid hormone receptor-β agonist GC-1 induces cell proliferation in rat liver and pancreas. Endocrinology 2006 PMID: 16574785
• Chiellini A high-affinity subtype-selective agonist ligand for the thyroid hormone receptor. Chem.Biol. 1998 PMID: 9653548

Product Documents for GC 1