Chemical Name: 2-[4-[[4-Hydroxy-3-(1-methylethyl)phenyl]methyl]-3,5-dimethylphenoxy]acetic acid
Biological ActivityGC 1 is a thyromimetic; high affinity agonist at thyroid hormone receptor (TR) β and TRα receptors (KD values are 67 and 440 pM respectively). Displays 5- and 100-fold greater potency than the endogenous agonist T3 in vitro at TRα1 and TRβ1 receptors respectively. Promotes reverse cholesterol transport in chow- and fat-fed mice. Induces proliferation of hepatocytes and pancreatic acinar cells in rats independent of prior tissue injury.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Selective thyroid receptor modulation by GC-1 reduces serum lipids stimulates steps of reverse cholesterol transport in euthyroid mice.
Johansson, L et al.
PNAS 102(29): 10297-10302.
A high-affinity subtype-selective agonist ligand for the thyroid hormone receptor.
Chiellini et al.
The thyroid hormone receptor-β agonist GC-1 induces cell proliferation in rat liver and pancreas.
Columbano et al.
Citations for GC 1
The citations listed below are publications that use Tocris products. Selected citations for GC 1 include:
3 Citations: Showing 1 - 3
Fatty acid oxidation is required for active and quiescent brown adipose tissue maintenance and thermogenic programing.
Authors: Gonzalez-Hurtado Et al.
Mol Metab 2018;7:45
Ins. mutations impair beta-cell development in a patient-derived iPSC model of neonatal diabetes.
Authors: Balboa Et al.
Clobetasol promotes remyelination in a mouse model of neuromyelitis optica.
Authors: Yao Et al.
Acta Neuropathol Commun 2016;4:42
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