GC 1

  ( 1 citations )    
Product Datasheet
Catalog Number:4554
Alternate Names:Sobetirome
Chemical Name:2-[4-[[4-Hydroxy-3-(1-methylethyl)phenyl]methyl]-3,5-dimethylphenoxy]acetic acid
Product Details
Citations (1)
Reviews
Biological Activity
Thyromimetic; high affinity agonist at thyroid hormone receptor (TR) β and TRα receptors (KD values are 67 and 440 pM respectively). Displays 5- and 100-fold greater potency than the endogenous agonist T3 in vitro at TRα1 and TRβ1 receptors respectively. Promotes reverse cholesterol transport in chow- and fat-fed mice. Induces proliferation of hepatocytes and pancreatic acinar cells in rats independent of prior tissue injury.
Technical Data
  • M.Wt:
    328.4
  • Formula:
    C20H24O4
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >98
  • Storage:
    Store at -20°C
  • CAS No:
    211110-63-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for GC 1 include:

1 Citations: Showing 1 - 1

  1. Clobetasol promotes remyelination in a mouse model of neuromyelitis optica.
    Authors: Yao Et al.
    Acta Neuropathol Commun  2016;4:42

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