Thyromimetic; high affinity agonist at thyroid hormone receptor (TR) β
values are 67 and 440 pM respectively). Displays 5- and 100-fold greater potency than the endogenous agonist T3 in vitro
receptors respectively. Promotes reverse cholesterol transport in chow- and fat-fed mice. Induces proliferation of hepatocytes and pancreatic acinar cells in rats independent of prior tissue injury.
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Selective thyroid receptor modulation by GC-1 reduces serum lipids and stimulates steps of reverse cholesterol transport in euthyroid mice.
Johansson, L et al.
Proc Natl Acad Sci U S A 102(29):10297-302.
A high-affinity subtype-selective agonist ligand for the thyroid hormone receptor.
Chiellini et al.
The thyroid hormone receptor-β agonist GC-1 induces cell proliferation in rat liver and pancreas.
Columbano et al.