Chemical Name: 2-[4-[[4-Hydroxy-3-(1-methylethyl)phenyl]methyl]-3,5-dimethylphenoxy]acetic acid
Biological ActivityThyromimetic; high affinity agonist at thyroid hormone receptor (TR) β and TRα receptors (KD values are 67 and 440 pM respectively). Displays 5- and 100-fold greater potency than the endogenous agonist T3 in vitro at TRα1 and TRβ1 receptors respectively. Promotes reverse cholesterol transport in chow- and fat-fed mice. Induces proliferation of hepatocytes and pancreatic acinar cells in rats independent of prior tissue injury.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Selective thyroid receptor modulation by GC-1 reduces serum lipids and stimulates steps of reverse cholesterol transport in euthyroid mice.
Johansson, L et al.
Proc Natl Acad Sci U S A 102(29):10297-302.
A high-affinity subtype-selective agonist ligand for the thyroid hormone receptor.
Chiellini et al.
The thyroid hormone receptor-β agonist GC-1 induces cell proliferation in rat liver and pancreas.
Columbano et al.
Citations for GC 1
The citations listed below are publications that use Tocris products. Selected citations for GC 1 include:
2 Citations: Showing 1 - 2
Fatty acid oxidation is required for active and quiescent brown adipose tissue maintenance and thermogenic programing.
Authors: Gonzalez-Hurtado Et al.
Mol Metab 2018;7:45
Clobetasol promotes remyelination in a mouse model of neuromyelitis optica.
Authors: Yao Et al.
Acta Neuropathol Commun 2016;4:42
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