GDC 0941

Key Product Details

Product Description

GDC 0941 is a potent pan PI3K inhibitor of class I catalytic subunits p110α, δ, β, and γ (IC₅₀ values are 3, 3, 33 and 75 nM, respectively). GDC 0941 inhibits the PI3K/AKT/mTOR signaling pathways and tumor cell growth in vitro and in vivo. GDC 0941 can be used in stem cell differentiation protocols to generate artery and vein endothelial cells from PSCs. GDC 0941 is orally bioavailable.

Product Specifications for GDC 0941

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for GDC 0941

The following data is based on the product molecular weight 513.64.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.95 mL	9.73 mL	19.47 mL
5 mM	0.39 mL	1.95 mL	3.89 mL
10 mM	0.19 mL	0.97 mL	1.95 mL
50 mM	0.04 mL	0.19 mL	0.39 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Loh Protocol for efficient generation of human artery and vein endothelial cells from pluripotent stem cells. STAR Protoc. 2025 PMID: 39705146
• Folkes The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer. J.Med.Chem. 2008 PMID: 18754654
• Ang Generating human artery and vein cells from pluripotent stem cells highlights the arterial tropism of Nipah and Hendra viruses. Cell 2022 PMID: 35738284

Product Documents for GDC 0941