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GDC 0941

Catalog #: 8905 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
8905/50
8905/10

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GDC 0941 | CAS No. 957054-30-7 | PI 3-Kinase Inhibitors
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Description: Potent pan-class I PI3 kinase inhibitor

Chemical Name: 2-(1H-Indazol-4-yl)-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)-thieno[3,2-d]pyrimidine

Purity: ≥98%

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Biological Activity

GDC 0941 is a potent pan PI3K inhibitor of class I catalytic subunits p110α, δ, β, and γ (IC50 values are 3, 3, 33 and 75 nM, respectively). GDC 0941 inhibits the PI3K/AKT/mTOR signaling pathways and tumor cell growth in vitro and in vivo. GDC 0941 can be used in stem cell differentiation protocols to generate artery and vein endothelial cells from PSCs. GDC 0941 is orally bioavailable.

Technical Data

M.Wt:
513.64
Formula:
C23H27N7O3S2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
957054-30-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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