Gedunin

  ( 2 citations )    
Product Datasheet
Catalog Number:3387
Chemical Name:(1S,3aS,4aR,4bS,5R,6aR,10aR,10bR,12aS)-5-(Acetyloxy)-1-(3-furanyl)-1,5,6,6a,7,10a,10b,11,12,12a,decahydro-4b,7,7,10a,12a,-pentamethyloxireno[c]phenanthro[1,2-d]pyran-3,8(3aH,4bH)-dione
Product Details
Citations (2)
Reviews
Biological Activity
Naturally occurring Hsp90 inhibitor. Induces Hsp90-dependent client protein degradation and displays antiproliferative activity in vitro (IC50 values are 3.22, 8.84 and 16.8 μM in SKBr3, MCF-7 and CaCo-2 cancer cell lines respectively). Decreases ovarian cancer cell proliferation in vitro and may enhance cisplatin-induced reduction in proliferation (CAT.No 3387). Also exhibits antimalarial activity against P. falciparum (IC50 values are 0.14 and 3.1 μM in parasite development and [3H]-hypoxanthine uptake assays respectively).
Technical Data
  • M.Wt:
    482.57
  • Formula:
    C28H34O7
  • Solubility:
    Soluble to 100 mM in DMSO and to 10 mM in ethanol with gentle warming
  • Purity:
    >98
  • Storage:
    Store at +4°C
  • CAS No:
    2753-30-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Gedunin include:

2 Citations: Showing 1 - 2
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  1. Optimization of a Fluorescence-Based Assay for Large-Scale Drug Screening against Babesia and Theileria Parasites.
    Authors: Rizk Et al.
    PLoS One  2015;10:e0125276
  2. Celastrol suppresses invasion of colon and pancreatic cancer cells through the downregulation of expression of CXCR4 chemokine receptor.
    Authors: Yadav Et al.
    J Mol Med (Berl)  2010;88:1243

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