Gedunin

Catalog # Availability Size / Price Qty
3387/1
Gedunin | CAS No. 2753-30-2 | HSP90 Inhibitors
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Description: Hsp90 inhibitor; exhibits anticancer and antimalarial activity

Chemical Name: (1S,3aS,4aR,4bS,5R,6aR,10aR,10bR,12aS)-5-(Acetyloxy)-1-(3-furanyl)-1,5,6,6a,7,10a,10b,11,12,12a,decahydro-4b,7,7,10a,12a,-pentamethyloxireno[c]phenanthro[1,2-d]pyran-3,8(3aH,4bH)-dione

Product Details
Citations (2)
Reviews (1)

Biological Activity

Naturally occurring Hsp90 inhibitor. Induces Hsp90-dependent client protein degradation and displays antiproliferative activity in vitro (IC50 values are 3.22, 8.84 and 16.8 μM in SKBr3, MCF-7 and CaCo-2 cancer cell lines respectively). Decreases ovarian cancer cell proliferation in vitro and may enhance cisplatin-induced reduction in proliferation (CAT.No 3387). Also exhibits antimalarial activity against P. falciparum (IC50 values are 0.14 and 3.1 μM in parasite development and [3H]-hypoxanthine uptake assays respectively).

Technical Data

Formula:
C28H34O7
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol with gentle warming
Storage:
Store the unopened product at 2 - 8 °C. Do not use past expiration date.
CAS No:
2753-30-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Gedunin

The citations listed below are publications that use Tocris products. Selected citations for Gedunin include:

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Gedunin used to demonstrate anti-proliferative activity
By Rutsha L Phillips on 12/14/2019
Species: Human

Gedunin used to demonstrate anti-proliferative activity against prostate cancer cell line. The depletion of cellular levels of Hsp90-dependent client proteins was scrutinised.


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