Naturally occurring Hsp90 inhibitor. Induces Hsp90-dependent client protein degradation and displays antiproliferative activity in vitro
values are 3.22, 8.84 and 16.8 μ
M in SKBr3, MCF-7 and CaCo-2 cancer cell lines respectively). Also exhibits antimalarial activity against P. falciparum
values are 0.14 and 3.1 μ
M in parasite development and [3
H]-hypoxanthine uptake assays respectively).
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All Tocris products are intended for laboratory research use only.
Gedunin, a limonoid from Xylocarpus granatum, inhibits the growth of CaCo-2 colon cancer cell line in vitro.
Uddin et al.
Gedunin, a novel Hsp90 inhibitor: semisynthesis of derivatives and preliminary structure-activity relationships.
Brandt et al.
Antimalarial activity of anthothecol derived from Khaya anthotheca (Meliaceae).
Lee et al.
The citations listed below are publications that use Tocris products. Selected citations for Gedunin include:
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