Gedunin

Tocris Bioscience | Catalog # 3387

Hsp90 inhibitor; exhibits anticancer and antimalarial activity
Tocris Bioscience

Key Product Details

Description

Hsp90 inhibitor; exhibits anticancer and antimalarial activity
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Product Description

Gedunin is a naturally occurring Hsp90 inhibitor. Induces Hsp90-dependent client protein degradation and displays antiproliferative activity in vitro (IC50 values are 3.22, 8.84 and 16.8 μM in SKBr3, MCF-7 and CaCo-2 cancer cell lines respectively). Decreases ovarian cancer cell proliferation in vitro and may enhance cisplatin-induced reduction in proliferation (CAT.No 3387). Also exhibits antimalarial activity against Plasmodium falciparum (IC50 values are 0.14 and 3.1 μM in parasite development and [3H]-hypoxanthine uptake assays respectively).

Product Specifications for Gedunin

Molecular Weight

482.57

Formula

C28H34O7

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

(1S,3aS,4aR,4bS,5R,6aR,10aR,10bR,12aS)-5-(Acetyloxy)-1-(3-furanyl)-1,5,6,6a,7,10a,10b,11,12,12a,decahydro-4b,7,7,10a,12a,-pentamethyloxireno[c]phenanthro[1,2-d]pyran-3,8(3aH,4bH)-dione

CAS Number

2753-30-2

PubChem ID

12004512

InChI Key

YJXDGWUNRYLINJ-BHAPSIHVSA-N

SMILES

O=C4[C@@H]6[C@]3(O6)[C@]2(C)[C@H](OC(C)=O)C[C@@]1([H])C(C)(C)C(C=C[C@@](C)1[C@]([H])2CC[C@](C)3[C@H]([C@]5=COC=C5)O4)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 48.26 100
Ethanol 4.83 10 with gentle warming

Preparing Stock Solutions for Gedunin

The following data is based on the product molecular weight 482.57.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.07 mL 10.36 mL 20.72 mL
5 mM 0.41 mL 2.07 mL 4.14 mL
10 mM 0.21 mL 1.04 mL 2.07 mL
50 mM 0.04 mL 0.21 mL 0.41 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 13 publications citing the usage of this product.

Product Documents for Gedunin

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Gedunin

For research use only

Customer Reviews for Gedunin (1)

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  • Gedunin used to demonstrate anti-proliferative activity
    Name: Rutsha L Phillips
    Species: Human
    Verified Customer | Posted 12/14/2019
    Gedunin used to demonstrate anti-proliferative activity against prostate cancer cell line. The depletion of cellular levels of Hsp90-dependent client proteins was scrutinised.
    Gedunin 3387

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