Catalog Number: 3387
Chemical Name: (1S,3aS,4aR,4bS,5R,6aR,10aR,10bR,12aS)-5-(Acetyloxy)-1-(3-furanyl)-1,5,6,6a,7,10a,10b,11,12,12a,decahydro-4b,7,7,10a,12a,-pentamethyloxireno[c]phenanthro[1,2-d]pyran-3,8(3aH,4bH)-dione
Biological Activity
Naturally occurring Hsp90 inhibitor. Induces Hsp90-dependent client protein degradation and displays antiproliferative activity in vitro (IC50 values are 3.22, 8.84 and 16.8 μM in SKBr3, MCF-7 and CaCo-2 cancer cell lines respectively). Decreases ovarian cancer cell proliferation in vitro and may enhance cisplatin-induced reduction in proliferation (CAT.No 3387). Also exhibits antimalarial activity against P. falciparum (IC50 values are 0.14 and 3.1 μM in parasite development and [3H]-hypoxanthine uptake assays respectively).
Technical Data
  • M.Wt:
    482.57
  • Formula:
    C28H34O7
  • Solubility:
    Soluble to 100 mM in DMSO and to 10 mM in ethanol with gentle warming
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    2753-30-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Gedunin, a limonoid from Xylocarpus granatum, inhibits the growth of CaCo-2 colon cancer cell line in vitro.
    Uddin et al.
    Phytother.Res., 2007;21:757
  2. Gedunin, a novel Hsp90 inhibitor: semisynthesis of derivatives and preliminary structure-activity relationships.
    Brandt et al.
    J.Med.Chem., 2008;51:6495
  3. Antimalarial activity of anthothecol derived from Khaya anthotheca (Meliaceae).
    Lee et al.
    Phytomedicine, 2008;15:533
  4. Gedunin, a novel natural substance, inhibits ovarian cancer cell proliferation.
    Kamath et al.
    Int J Gynecol Cancer., 2009;19:1564
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Gedunin include:

2 Citations: Showing 1 - 2
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  1. Optimization of a Fluorescence-Based Assay for Large-Scale Drug Screening against Babesia and Theileria Parasites.
    Authors: Rizk Et al.
    PLoS One 2015;10:e0125276
  2. Celastrol suppresses invasion of colon and pancreatic cancer cells through the downregulation of expression of CXCR4 chemokine receptor.
    Authors: Yadav Et al.
    J Mol Med (Berl) 2010;88:1243

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