Very potent and selective inhibitor of protein kinase C, selective for the α
1 isoforms (IC50
values are 0.0084, 0.0180, 0.210, 0.132, and 5.8 μ
M for α
isoforms respectively). Selective over MLCK, PKG and PKA (IC50
values are 0.6, 4.6, and 33 μ
M respectively). Potent antagonist at the 5-HT3
= 29.5 nM). Anti-inflammatory in vivo
Soluble to 25 mM in DMSO
Store at RT
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.