GIP (human)

Catalog # Availability Size / Price Qty
2084/1
GIP (human)
1 Image
Description: Potent insulinotropic gut hormone; GIP agonist
Alternative Names: Gastric Inhibitory Polypeptide (human)
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Biological Activity

Potent insulinotropic hormone synthesized by duodenal K-cells. High affinity GIP receptor agonist (EC50 = 0.81 nM) that inhibits gastric acid secretion and stimulates pancreatic insulin release in response to glucose. Also affects lipid metabolism and displays mitogenic and antiapoptotic effects in pancreatic β-cells.

Technical Data

M.Wt:
4983.58
Formula:
C226H338N60O66S
Sequence:
YAEGTFISDYSIAMDKIHQQDFVNWLLAQKGKKNDWKHNITQ
Solubility:
Soluble to 1 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
100040-31-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Functional expression of the rat pancreatic islet glucose-dependent Insotropic polypeptide receptor: ligand binding and intracellular signaling properties.
    Wheeler et al.
    Endocrinol., 1995;136:4629
  2. Glucose-dependent Insotropic polypeptide is a growth factor for β (INS-1) cells by pleiotropic signaling.
    Trumper et al.
    Mol.Endocrinol., 2001;15:1159
  3. Gastric inhibitory polypeptide: the neglected incretin revisited.
    Meier et al.
    Regul.Peptides, 2002;107:1

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