Biological ActivityGIP (human) is a potent insulinotropic hormone synthesized by duodenal K-cells. High affinity GIP receptor agonist (EC50 = 0.81 nM) that inhibits gastric acid secretion and stimulates pancreatic insulin release in response to glucose. Also affects lipid metabolism and displays mitogenic and antiapoptotic effects in pancreatic β-cells.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Functional expression of the rat pancreatic islet glucose-dependent Insotropic polypeptide receptor: ligand binding and intracellular signaling properties.
Wheeler et al.
Glucose-dependent Insotropic polypeptide is a growth factor for β (INS-1) cells by pleiotropic signaling.
Trumper et al.
Gastric inhibitory polypeptide: the neglected incretin revisited.
Meier et al.
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