GIPR Antibody (591827) [HRP]

Novus Biologicals | Catalog # MAB82102H

Novus Biologicals

Key Product Details

Species Reactivity

Human

Applications

Label

HRP

Antibody Source

Monoclonal Mouse IgG1 Clone # 591827
View all GIPR Primary Antibodies »

Product Specifications

Immunogen

NS0 mouse myeloma cell line transfected with human GIPR (amino acids 1-466)

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Description

>90% by SDS PAGE

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

PBS

Preservative

No Preservative

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: GIPR

GIPR, or Gastric Inhibitory Polypeptide Receptor, mediates GIP-induced secretion of insulin by pancreatic islet beta cells after a meal. GIP is a gastrointestinal peptide hormone of 42 aa that is released from duodenal endocrine K cells after absorption of glucose or fat. Stimulation of the GIPR on pancreatic cells activates adenylyl cyclase and mitogen-activated protein kinase, resulting in increased insulin secretion. Mice with a targeted mutation of GIPR have higher blood glucose levels with impaired initial insulin response after oral glucose load. Analysis of GIPR knockout mice suggest that GIPR defects may contribute to the pathogenesis of diabetes and obesity. Ectopic expression of functional GIPR and its coupling to steroidogenesis has been suggested to be the main cause of food-dependent Cushing's syndrome. Two isoforms of GIPR are produced by alternative splicing. GIPR expression has been reported in human bone, fetal adrenal, and pancreas. Little expression has been identified in normal adult adrenal, but overexpression of GIPR has been observed in the adrenal in food-dependent Cushing's syndrome. GIPR expression has been identified in rat brain, heart, pancreas, and small intestine. ESTs have been isolated from colon libraries.

Long Name

Gastric Inhibitory Polypeptide Receptor

Alternate Names

PGQTL2

Gene Symbol

GIPR

Additional GIPR Products

Product Documents for GIPR Antibody (591827) [HRP]

Certificate of Analysis

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Product Specific Notices for GIPR Antibody (591827) [HRP]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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