GIT 27

  ( 1 citations )    
Product Datasheet
Catalog Number:3270
Chemical Name:4,5-Dihydro-3-phenyl-5-isoxazoleacetic acid
Product Details
Citations (1)
Reviews
Biological Activity
Orally active immunomodulatory agent that primarily targets macrophages. Inhibits TNF-α secretion via interference of macrophage toll-like receptor (TLR) 4 and TLR 2/6 signaling pathway. Also reduces the secretion of pro-inflammatory cytokines IL1-β, IL-10 and IFN-γ. Antidiabetogenic; prevents IL-β and IFN-γ-induced pancreatic islet cell death in vitro.
Technical Data
  • M.Wt:
    205.21
  • Formula:
    C11H11NO3
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99
  • Storage:
    Store at +4°C
  • CAS No:
    6501-72-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for GIT 27 include:

1 Citations: Showing 1 - 1

  1. Podocyte apoptosis is prevented by blocking the Toll-like receptor pathway.
    Authors: Saurus Et al.
    Cell Death Dis  2015;6:e1752

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