GIT 27

Catalog # Availability Size / Price Qty
GIT 27 | CAS No. 6501-72-0 | Cytokine Compounds
1 Image
Description: Immunomodulator; reduces production of pro-inflammatory cytokines

Chemical Name: 4,5-Dihydro-3-phenyl-5-isoxazoleacetic acid

Purity: ≥98%

Product Details
Citations (1)

Biological Activity

GIT 27 is an orally active immunomodulatory agent that primarily targets macrophages. Inhibits TNF-α secretion via interference of macrophage toll-like receptor (TLR) 4 and TLR 2/6 signaling pathway. Also reduces the secretion of pro-inflammatory cytokines IL1-β, IL-10 and IFN-γ. Antidiabetogenic; prevents IL-β and IFN-γ-induced pancreatic islet cell death in vitro.

Technical Data

Soluble to 100 mM in DMSO
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for GIT 27

The citations listed below are publications that use Tocris products. Selected citations for GIT 27 include:

1 Citation: Showing 1 - 1

  1. Podocyte apoptosis is prevented by blocking the Toll-like receptor pathway.
    Authors: Saurus Et al.
    Cell Death Dis  2015;6:e1752


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