Catalog Number: 0219
Chemical Name: Aminoethanoic acid
Biological Activity
One of the major inhibitory neurotransmitters in the mammalian CNS, predominantly active in the spinal cord and brain stem. Also acts as a modulator of excitatory amino acid transmission mediated by NMDA receptors. Also available as part of the NMDA Receptor - Glycine Site Tocriset™.
Technical Data
  • M.Wt:
    75.07
  • Formula:
    C2H5NO2
  • Solubility:
    Soluble to 100 mM in water
  • Storage:
    Store at RT
  • CAS No:
    56-40-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Synthesis of S-[3-(4(5)-imidazolyl)propyl]-N-[2-(4-[125I]-iodophenylethyl]isothiourea sulfate [125I]-iodophenpropit), a new probe for histamine H3 receptor binding sites.
    Menge et al.
    J.Labelled Comp.Radiopharm. XXXI, 1992;10:781
  2. Glycine receptors: heterogeneous and widespread in the mammalian brain.
    Betz
    Trends Neurosci., 1991;14:458
  3. The inhibitory glycine receptor: architecture, synaptic localization and molecular pathology of a postsynaptic ion-channel complex.
    Kuhse et al.
    Curr.Opin.Neurobiol., 1995;5:318
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Glycine include:

2 Citations: Showing 1 - 2
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  1. Selective inhibition of KCC2 leads to hyperexcitability and epileptiform discharges in hippocampal slices and in vivo.
    Authors: Sivakumaran Et al.
    Front Cell Neurosci 2015;35:8291
  2. Mechanisms of microglia-mediated neurotoxicity in a new model of the stroke penumbra.
    Authors: Kaushal and Schlichter
    J Neurosci 2008;28:2221

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