Glycine

Catalog # Availability Size / Price Qty
0219/1G
Glycine | CAS No. 56-40-6 | Additional NMDA Receptor Compounds
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Description: Endogenous potentiator of NMDA receptors

Chemical Name: Aminoethanoic acid

Product Details
Citations (4)
Reviews (1)

Biological Activity

One of the major inhibitory neurotransmitters in the mammalian CNS, predominantly active in the spinal cord and brain stem. Also acts as a modulator of excitatory amino acid transmission mediated by NMDA receptors. Also available as part of the NMDA Receptor - Glycine Site Tocriset™.

Technical Data

M.Wt:
75.07
Formula:
C2H5NO2
Solubility:
Soluble to 100 mM in water
Storage:
Store at RT
CAS No:
56-40-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Olanzapine: preclinical and clinical profiles of a novel antipsychotic agent.
    Tollefson and Taylor
    CNS Drug Reviews, 2000;6:303
  2. Glycine receptors: heterogeneous and widespread in the mammalian brain.
    Betz
    Trends Neurosci., 1991;14:458
  3. The inhibitory glycine receptor: architecture, synaptic localization and molecular pathology of a postsynaptic ion-channel complex.
    Kuhse et al.
    Curr.Opin.Neurobiol., 1995;5:318
  4. Glycine potentiates the NMDA response in cultured mouse brain neurons.
    Johnson and Ascher
    Nature, 1987;325:529
  5. The NMDA receptor, its channel and its modulation by glycine.
    Ascher and Johnson
    The NMDA Receptor (2nd edition). Eds. G.L.Collingr, 1989;:109

Product Datasheets

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Citations for Glycine

The citations listed below are publications that use Tocris products. Selected citations for Glycine include:

4 Citations: Showing 1 - 4

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Reviews for Glycine

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Use of glycine as NMDA receptor co-agonist
By Anonymous on 10/19/2019
Application: Species: Human

Mixture of 100 microM of glycine + 100 microM NMDA was used to evoke an NMDA receptor response in outside-out patched excised from hippocampal neurons. Glycine displayed a clear co-agonist effect, as expected. Easily soluble, no problem if stored in frozen aliquots for more than half a year.


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