Chemical Name: Aminoethanoic acid
Biological ActivityOne of the major inhibitory neurotransmitters in the mammalian CNS, predominantly active in the spinal cord and brain stem. Also acts as a modulator of excitatory amino acid transmission mediated by NMDA receptors. Also available as part of the NMDA Receptor - Glycine Site Tocriset™.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Olanzapine: preclinical and clinical profiles of a novel antipsychotic agent.
Tollefson and Taylor
CNS Drug Reviews, 2000;6:303
Glycine receptors: heterogeneous and widespread in the mammalian brain.
Trends Neurosci., 1991;14:458
The inhibitory glycine receptor: architecture, synaptic localization and molecular pathology of a postsynaptic ion-channel complex.
Kuhse et al.
Glycine potentiates the NMDA response in cultured mouse brain neurons.
Johnson and Ascher
The NMDA receptor, its channel and its modulation by glycine.
Ascher and Johnson
The NMDA Receptor (2nd edition). Eds. G.L.Collingr, 1989;:109
Citations for Glycine
The citations listed below are publications that use Tocris products. Selected citations for Glycine include:
4 Citations: Showing 1 - 4
Neuronal Activity and Intracellular Calcium Levels Regulate Intracellular Transport of Newly Synthesized AMPAR.
Authors: Hangen Et al.
Cell Rep 2018;24:1001
Selective inhibition of KCC2 leads to hyperexcitability and epileptiform discharges in hippocampal slices and in vivo.
Authors: Sivakumaran Et al.
Front Cell Neurosci 2015;35:8291
The integrity of the glycine co-agonist binding site of N-MthD.-aspartate receptors is a functional quality control checkpoint for cell surface delivery.
Authors: Kenny Et al.
J Biol Chem 2009;284:324
Mechanisms of microglia-mediated neurotoxicity in a new model of the stroke penumbra.
Authors: Kaushal and Schlichter
J Neurosci 2008;28:2221
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for Glycine
Average Rating: 5 (Based on 1 Review)
Have you used Glycine?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Mixture of 100 microM of glycine + 100 microM NMDA was used to evoke an NMDA receptor response in outside-out patched excised from hippocampal neurons. Glycine displayed a clear co-agonist effect, as expected. Easily soluble, no problem if stored in frozen aliquots for more than half a year.