Glycyl-H 1152 dihydrochloride

Catalog # Availability Size / Price Qty
2485/1
Glycyl-H 1152 dihydrochloride | CAS No. 913844-45-8 | Rho-kinase Inhibitors
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Description: Selective Rho-kinase (ROCK) inhibitor. More selective analog of H 1152 dihydrochloride (Cat. No. 2414)

Chemical Name: (S)-(+)-4-Glycyl-2-methyl-1-[(4-methyl-5-isoquinolinyl)sulfonyl]-hexahydro-1H-1,4-diazepine dihydrochloride

Purity: ≥99%

Product Details
Citations (4)
Supplemental Products
Reviews

Biological Activity

Glycyl analog of the Rho-kinase inhibitor H 1152 dihydrochloride (Cat. No. 2414) that displays improved ROCKII selectivity. IC50 values are 0.0118, 2.35, 2.57, 3.26, > 10 and >10 μM for ROCKII, Aurora A, CAMKII, PKG, PKA and PKC respectively.

Technical Data

M.Wt:
449.4
Formula:
C18H24N4O3S.2HCl
Solubility:
Soluble to 100 mM in water and to 50 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
913844-45-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Development of specific Rho-kinase inhibitors and their clinical application.
    Tamura et al.
    Biochim.Biophys.Acta, 2005;1754:245

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Citations for Glycyl-H 1152 dihydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Glycyl-H 1152 dihydrochloride include:

4 Citations: Showing 1 - 4

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