Glycyl-H 1152 dihydrochloride
Chemical Name: (S)-(+)-4-Glycyl-2-methyl-1-[(4-methyl-5-isoquinolinyl)sulfonyl]-hexahydro-1H-1,4-diazepine dihydrochloride
Biological ActivityGlycyl analog of the Rho-kinase inhibitor H 1152 dihydrochloride (Cat. No. 2414) that displays improved ROCKII selectivity. IC50 values are 0.0118, 2.35, 2.57, 3.26, > 10 and >10 μM for ROCKII, Aurora A, CAMKII, PKG, PKA and PKC respectively.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Development of specific Rho-kinase inhibitors and their clinical application.
Tamura et al.
Citations for Glycyl-H 1152 dihydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Glycyl-H 1152 dihydrochloride include:
4 Citations: Showing 1 - 4
Rapid dispersion of SynGAP from synaptic spines triggers AMPA receptor insertion and spine enlargement during LTP.
Authors: Araki Et al.
PLoS One 2015;85:173
Transport of organic anions and cations in murine embryonic kidney development and in serially-reaggregated engineered kidneys.
Authors: Lawrence Et al.
Sci Rep 2015;5:9092
Cell-based screen for altered nuclear phenotypes reveals senescence progression in polyploid cells after Aurora kinase B inhibition.
Authors: Sadaie Et al.
Mol Biol Cell 2015;26:2971
Contribution of human amniotic fluid stem cells to renal tissue formation depends on mTOR.
Authors: Siegel Et al.
Hum Mol Genet 2010;19:3320
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