Glycyl-H 1152 dihydrochloride
Chemical Name: (S)-(+)-4-Glycyl-2-methyl-1-[(4-methyl-5-isoquinolinyl)sulfonyl]-hexahydro-1H-1,4-diazepine dihydrochloride
Biological ActivityGlycyl-H 1152 dihydrochloride is a glycyl analog of the Rho-kinase inhibitor H 1152 dihydrochloride (Cat. No. 2414) that displays improved ROCKII selectivity. IC50 values are 0.0118, 2.35, 2.57, 3.26, > 10 and >10 μM for ROCKII, Aurora A, CAMKII, PKG, PKA and PKC respectively.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Development of specific Rho-kinase inhibitors and their clinical application.
Tamura et al.
Citations for Glycyl-H 1152 dihydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Glycyl-H 1152 dihydrochloride include:
4 Citations: Showing 1 - 4
Rapid dispersion of SynGAP from synaptic spines triggers AMPA receptor insertion and spine enlargement during LTP.
Authors: Araki Et al.
PLoS One 2015;85:173
Transport of organic anions and cations in murine embryonic kidney development and in serially-reaggregated engineered kidneys.
Authors: Lawrence Et al.
Sci Rep 2015;5:9092
Cell-based screen for altered nuclear phenotypes reveals senescence progression in polyploid cells after Aurora kinase B inhibition.
Authors: Sadaie Et al.
Mol Biol Cell 2015;26:2971
Contribution of human amniotic fluid stem cells to renal tissue formation depends on mTOR.
Authors: Siegel Et al.
Hum Mol Genet 2010;19:3320
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