Catalog Number: 2485
Chemical Name: (S)-(+)-4-Glycyl-2-methyl-1-[(4-methyl-5-isoquinolinyl)sulfonyl]-hexahydro-1H-1,4-diazepine dihydrochloride
Biological Activity
Glycyl analog of the Rho-kinase inhibitor H 1152 dihydrochloride (Cat. No. 2414) that displays improved ROCKII selectivity. IC50 values are 0.0118, 2.35, 2.57, 3.26, > 10 and >10 μM for ROCKII, Aurora A, CAMKII, PKG, PKA and PKC respectively.
Technical Data
  • M.Wt:
    449.4
  • Formula:
    C18H24N4O3S.2HCl
  • Solubility:
    Soluble to 100 mM in water and to 50 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Desiccate at RT
  • CAS No:
    913844-45-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Development of specific Rho-kinase inhibitors and their clinical application.
    Tamura et al.
    Biochim.Biophys.Acta, 2005;1754:245
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Glycyl-H 1152 dihydrochloride include:

4 Citations: Showing 1 - 4
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  1. Rapid dispersion of SynGAP from synaptic spines triggers AMPA receptor insertion and spine enlargement during LTP.
    Authors: Araki Et al.
    PLoS One 2015;85:173
  2. Transport of organic anions and cations in murine embryonic kidney development and in serially-reaggregated engineered kidneys.
    Authors: Lawrence Et al.
    Sci Rep 2015;5:9092
  3. Cell-based screen for altered nuclear phenotypes reveals senescence progression in polyploid cells after Aurora kinase B inhibition.
    Authors: Sadaie Et al.
    Mol Biol Cell 2015;26:2971
  4. Contribution of human amniotic fluid stem cells to renal tissue formation depends on mTOR.
    Authors: Siegel Et al.
    Hum Mol Genet 2010;19:3320
Tocris Small Molecules
Description Application Cat# Citations Images  

H 1152 dihydrochloride

2414 4  
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