H 1152 dihydrochloride

  ( 10 citations )    
Product Datasheet
Catalog Number:2414
Chemical Name:(S)-(+)-2-Methyl-1-[(4-methyl-5-isoquinolinyl)sulfonyl]-hexahydro-1H-1,4-diazepine dihydrochloride
Product Details
Citations (10)
Biological Activity
Rho-kinase (ROCK) inhibitor that displays high selectivity over other protein kinases (IC 50 values are 0.012, 0.180, 0.360, 0.745, 3.03, 5.68 and 28.3 μM for ROCKII, CAMKII, PKG, Aurora A, PKA, PKC and MLCK respectively). Inhibits sulprostone-induced contractions in guinea pig aorta (IC 50 = 190 nM) and displays proerectile effects in rats. Glycyl Derivative also available.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water and to 50 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
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The citations listed below are publications that use Tocris products. Selected citations for H 1152 dihydrochloride include:

10 Citations: Showing 1 - 10
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  1. ROCK signaling promotes collagen remodeling to facilitate invasive pancreatic ductal adenocarcinoma tumor cell growth.
    Authors: Rath Et al.
    EMBO Mol Med  2017;9:198
  2. Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling.
    Authors: Berenjeno Et al.
    Nat Commun  2017;8:1773
  3. Multiparametric Analysis of Cell Shape Demonstrates that β-PIX Directly Couples YAP Activation to Extracellular Matrix Adhesion.
    Authors: Sero and Bakal
    Cell Syst  2017;4:84
  4. RhoD Inhibits RhoC-ROCK-Dependent Cell Contraction via PAK6.
    Authors: Durkin Et al.
    Dev Cell  2017;41:315
  5. Anoctamin 6 Contributes to Cl- Secretion in Accessory Cholera Enterotoxin (Ace)-stimulated Diarrhea: AN ESSENTIAL ROLE FOR PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE (PIP2) SIGNALING IN CHOLERA.
    Authors: Aoun Et al.
    J Biol Chem  2016;291:26816
  6. Cell shape and the microenvironment regulate nuclear translocation of NF-κB in breast epithelial and tumor cells.
    Authors: Sero Et al.
    Mol Syst Biol  2015;11:790
  7. Cell shape and the microenvironment regulate nuclear translocation of NF-κB in breast epithelial and tumor cells.
    Authors: Sero Et al.
    Mol Syst Biol  2015;11:790
  8. Activation of RhoA,B,C by Yersinia Cytotoxic Necrotizing Factor (CNFy) induces apoptosis in LNCaP prostate cancer cells.
    Authors: Augspach Et al.
    Toxins (Basel)  2013;5:2241
  9. Roco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutations.
    Authors: Gilsbach Et al.
    Proc Natl Acad Sci U S A  2012;109:10322
  10. Cytoskeletal changes underlie estrogen's acute effects on synaptic transmission and plasticity.
    Authors: Kramár Et al.
    J Clin Pharmacol  2009;29:12982


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