Rho-kinase (ROCK) inhibitor that displays high selectivity over other protein kinases (IC50
values are 0.012, 0.180, 0.360, 0.745, 3.03, 5.68 and 28.3 μ
M for ROCKII, CAMKII, PKG, Aurora A, PKA, PKC and MLCK respectively). Inhibits sulprostone-induced contractions in guinea pig aorta (IC50
= 190 nM) and displays proerectile effects in rats. Glycyl derivative
available (Cat. No. 2485).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Other Product-Specific Information:
Involvement of Rho-kinase in contraction of guinea-pig aorta induced by prostanoid EP3 receptor agonist.
Shum et al.
Proerectile effects of the rho-kinase inhibitor (S)-(+)-2-methyl-1-[(4-methyl-5-isoquinolinyl)sulfonyl]homopiperazine (H-1152) in the rat penis.
Teixeira et al.
Development of specific Rho-kinase inhibitors and their clinical application.
Tamura et al.
The citations listed below are publications that use Tocris products. Selected citations for H 1152 dihydrochloride include:
Showing Results 1 - 4 of 4