H 1152 dihydrochloride

Tocris Bioscience | Catalog # 2414

Selective Rho-kinase (ROCK) inhibitor
Tocris Bioscience

Key Product Details

Description

Selective Rho-kinase (ROCK) inhibitor
View all Rho-kinase Inhibitors »

Product Description

H 1152 dihydrochloride is a rho-kinase (ROCK) inhibitor that displays high selectivity over other protein kinases (IC50 values are 0.012, 0.180, 0.360, 0.745, 3.03, 5.68 and 28.3 μM for ROCKII, CAMKII, PKG, Aurora A, PKA, PKC and MLCK respectively). Inhibits sulprostone-induced contractions in guinea pig aorta (IC50 = 190 nM) and displays proerectile effects in rats.

Glycyl Derivative also available.

Product Specifications for H 1152 dihydrochloride

Molecular Weight

392.34

Formula

C16H21N3O2S.2HCl

Storage

Desiccate at +4°C

Purity

≥98% (HPLC)

Chemical Name

(S)-(+)-2-Methyl-1-[(4-methyl-5-isoquinolinyl)sulfonyl]-hexahydro-1H-1,4-diazepine dihydrochloride

CAS Number

871543-07-6

PubChem ID

11560225

InChI Key

BFOPDSJOLUQULZ-GXKRWWSZSA-N

SMILES

CC1=CN=CC2=C1C(S(N3CCCNC[C@@H]3C)(=O)=O)=CC=C2.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 39.23 100
DMSO 19.62 50

Preparing Stock Solutions for H 1152 dihydrochloride

The following data is based on the product molecular weight 392.34.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.55 mL 12.74 mL 25.49 mL
5 mM 0.51 mL 2.55 mL 5.10 mL
10 mM 0.25 mL 1.27 mL 2.55 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 34 publications citing the usage of this product.

Product Documents for H 1152 dihydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for H 1152 dihydrochloride

For research use only

Citations for H 1152 dihydrochloride

Customer Reviews for H 1152 dihydrochloride (4)

4.8 out of 5
4 Customer Ratings
5 Stars
75%
4 Stars
25%
3 Stars
0%
2 Stars
0%
1 Stars
0%

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  • In vitro study
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Verified Customer | Posted 06/25/2021
    Different Concentration were tested in vitro and lysates were collected.
  • In vitro
    Name: Anonymous
    Species: Human
    Verified Customer | Posted 02/28/2021
    Dihydrochloride were added at different time points to collect RNA and lysates
  • H1152 for spiral ganglion neuron differentiation
    Name: Minjin Jeong
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: iPSCs
    Verified Customer | Posted 08/09/2019
    H1152 is slightly better than Y27632 for neuronal differentiation.
    H1152 is used for spiral ganglion neuron differentiation.
  • In Vitro studay
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue:
    Verified Customer | Posted 02/08/2019
    DMSO, 1uM and 10 μM H1152 dihydrochloride were added to cells for 24h for western.

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