Chemical Name: N-2-Naphthalenyl-2-[(3,5-dibromo-2,4-dihydroxyphenyl)methylene]glycine hydrazide
Biological ActivityReversible, voltage-dependent CFTR chloride channel blocker (Ki = 4.3 μM). Inhibits forskolin-induced hyperpolarization in nasal potential differences and inhibits cholera toxin-induced intestinal fluid secretion in mice.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Discovery of glycine hydrazide pore-occluding CFTR inhibitors: mechanism, structure-activity analysis, and in vivo efficacy.
Muanprasat et al.
Locating a plausible binding site for an open-channel blocker, GlyH-101, in the pore of the cystic fibrosis transmembrane conductance regulator.
Norimatsu et al.
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