Reversible, voltage-dependent CFTR chloride channel blocker (Ki
= 4.3 μ
M). Inhibits forskolin
-induced hyperpolarization in nasal potential differences and inhibits cholera toxin-induced intestinal fluid secretion in mice.
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All Tocris products are intended for laboratory research use only.
Discovery of glycine hydrazide pore-occluding CFTR inhibitors: mechanism, structure-activity analysis, and in vivo efficacy.
Muanprasat et al.
Locating a plausible binding site for an open-channel blocker, GlyH-101, in the pore of the cystic fibrosis transmembrane conductance regulator.
Norimatsu et al.