GN 44028

Key Product Details

Product Description

GN 44028 is a potent HIF-1α inhibitor (IC₅₀ = 14 nM). Inhibits hypoxia-induced HIF-1α transcriptional activity without suppressing HIF-1α mRNA expression, HIF-1α protein accumulation, or HIF-1α/HIF-1β heterodimerization. Cytotoxic to a range of cancer cell types in vitro.

Product Specifications for GN 44028

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for GN 44028

The following data is based on the product molecular weight 305.33.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.28 mL	16.38 mL	32.75 mL
5 mM	0.66 mL	3.28 mL	6.55 mL
10 mM	0.33 mL	1.64 mL	3.28 mL
50 mM	0.07 mL	0.33 mL	0.66 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 4 publications citing the usage of this product.

• Minegishi Discovery of indenopyrazoles as a new class of hypoxia inducible factor (HIF)-1 inhibitors. ACS Med.Chem.Lett. 2013 PMID: 24900662

Product Documents for GN 44028