= 14 nM). Inhibits hypoxia-induced HIF-1α
transcriptional activity without suppressing HIF-1α
mRNA expression, HIF-1α
protein accumulation, or HIF-1α
heterodimerization. Cytotoxic to a range of cancer cell types in vitro
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All Tocris products are intended for laboratory research use only.
Discovery of indenopyrazoles as a new class of hypoxia inducible factor (HIF)-1 inhibitors.
Minegishi et al.
ACS Med.Chem.Lett., 2013;4:297