GNE 9278

Catalog # Availability Size / Price Qty
6369/10
6369/50
NMDA Receptor Modulators Small Molecule
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Description: Positive allosteric modulator of NMDA receptors; acts in transmembrane domain

Chemical Name: 4-Cyclohexyl-N-(7-hydroxy-5-methyl-2-propyl[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)benzenesulfonamide

Purity: ≥98%

Product Details
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Biological Activity

Positive allosteric modulator of NMDA receptors. Potentiates NMDA receptors containing GluN2A, 2B, 2C and 2D subunits (EC50 values are 0.74, 3.07, 0.47 and 0.32 μM in a Ca2+ influx assay, respectively). Binds within the transmembrane domain and displays preference for agonist-bound NMDA receptors. Slows receptor deactivation and enhances the potency of glutamate and glycine.

Technical Data

M.Wt:
429.54
Formula:
C21H27N5O3S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
901230-11-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. A novel NMDA receptor positive allosteric modulator that acts via the transmembrane domain.
    Wang et al.
    Neuropharmacology., 2017;121:204

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