Go 6976

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2253/1
Go 6976 | CAS No. 136194-77-9 | Protein Kinase C Inhibitors
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Description: Potent protein kinase C inhibitor; selective for α and β isozymes

Chemical Name: 5,6,7,13-Tetrahydro-13-methyl-5-oxo-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-12-propanenitrile

Purity: ≥98%

Product Details
Citations (15)
Reviews

Biological Activity

Potent protein kinase C (PKC) inhibitor (IC50 = 7.9 nM). Discriminates between Ca2+-dependent and -independent isoforms of PKC in vitro; selectively inhibits PKCα and PKCβ1 (IC50 values are 2.3 and 6.2 nM respectively). Does not inhibit the activity of PKCδ, -ε, or -ζ (IC50 > 3μM). Also inhibits TrkA, TrkB, JAK2 and JAK3 tyrosine kinases (IC50 values are 5, 30, 130 and 370 nM respectively), PKCμ (PKD1) and the mitotic spindle checkpoint.

Technical Data

M.Wt:
378.43
Formula:
C24H18N4O
Solubility:
Soluble to 10 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
136194-77-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Go 6976

The citations listed below are publications that use Tocris products. Selected citations for Go 6976 include:

15 Citations: Showing 1 - 10

  1. Autophagy is required for lung development and morphogenesis.
    Authors: Yeganeh Et al.
    J Clin Invest  2019;130:2904
  2. Organic barn dust inhibits surfactant protein D production through protein kinase-c alpha dependent increase of GPR116.
    Authors: Schneberger Et al.
    PLoS One  2018;13:e0208597
  3. PKC-α Triggers EGFR Ubiquitination, Endocytosis and ERK Activation in Podocytes Stimulated with High Glucose.
    Authors: Lei Et al.
    Cell Physiol Biochem  2017;42:281
  4. Protein kinase D at the Golgi controls NLRP3 inflammasome activation.
    Authors: Zhang Et al.
    J Exp Med  2017;214:2671
  5. Cancer cells that survive checkpoint adaptation contain micronuclei that harbor damaged DNA.
    Authors: Lewis and Golsteyn
    Cell Cycle  2016;15:3131
  6. Tyrosine Binding Protein Sites Regulate the Intracellular Trafficking and Processing of Amyloid Precursor Protein through a Novel Lysosome-Directed Pathway.
    Authors: Tam Et al.
    PLoS One  2016;11:e0161445
  7. P53-dependent upregulation of neutral sphingomyelinase-2: role in doxorubicin-induced growth arrest.
    Authors: Shamseddine Et al.
    Cell Death Dis  2015;6:e1947
  8. Inhibition of protein kinase C by isojacareubin suppresses hepatocellular carcinoma metastasis and induces apoptosis in vitro and in vivo.
    Authors: Yuan Et al.
    Sci Rep  2015;5:12889
  9. Targeting a cell state common to triple-negative breast cancers.
    Authors: Muellner Et al.
    J Biol Chem  2015;11:789
  10. Orexin-A promotes cell migration in cultured rat astrocytes via Ca2+-dependent PKCα and ERK1/2 signals.
    Authors: Shu Et al.
    PLoS One  2014;9:e95259

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