Potent protein kinase C (PKC) inhibitor (IC50
= 7.9 nM). Discriminates between Ca2+
-dependent and -independent isoforms of PKC in vitro
; selectively inhibits PKCα
values are 2.3 and 6.2 nM respectively). Does not inhibit the activity of PKCδ
, or -ζ
M). Also inhibits TrkA, TrkB, JAK2 and JAK3 tyrosine kinases (IC50
values are 5, 30, 130 and 370 nM respectively), PKCμ
(PKD1) and the mitotic spindle checkpoint.
Soluble to 10 mM in DMSO
Desiccate at -20°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Pharmacologic abrogation of the mitotic spindle checkpoint by an indolocarbazole discovered by cellular screening efficiently kills cancer cells.
Stolz A, Vogel C, Schneider V et al.
Selective inhibition of protein kinase C isozymes by the indolocarbazole G� 6976
Martiny-Baron et al.
Immunological demonstration of protein kinase Cμ in murine tissues and various cell lines.
Rennecke et al.
Go 6976 is a potent inhibitor of neurotrophin-receptor intrinsic tyrosine kinase.
Behrens et al.
Go6976 is a potent inhibitor of JAK2 and FLT3 tyrosine kinases with significant activity in primary acute myeloid leukaemia cells.
Grandage et al.
The citations listed below are publications that use Tocris products. Selected citations for Go 6976 include:
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