Go 6976

  ( 8 citations )    
Product Datasheet
Catalog Number:2253
Chemical Name:5,6,7,13-Tetrahydro-13-methyl-5-oxo-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-12-propanenitrile
Product Details
Citations (8)
Reviews
Biological Activity
Potent protein kinase C (PKC) inhibitor (IC50 = 7.9 nM). Discriminates between Ca2+-dependent and -independent isoforms of PKC in vitro; selectively inhibits PKCα and PKCβ1 (IC50 values are 2.3 and 6.2 nM respectively). Does not inhibit the activity of PKCδ, -ε, or -ζ (IC50 > 3μM). Also inhibits TrkA, TrkB, JAK2 and JAK3 tyrosine kinases (IC50 values are 5, 30, 130 and 370 nM respectively), PKCμ (PKD1) and the mitotic spindle checkpoint.
Technical Data
  • M.Wt:
    378.43
  • Formula:
    C24H18N4O
  • Solubility:
    Soluble to 10 mM in DMSO
  • Purity:
    >98
  • Storage:
    Desiccate at -20°C
  • CAS No:
    136194-77-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Go 6976 include:

8 Citations: Showing 1 - 8
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  1. P53-dependent upregulation of neutral sphingomyelinase-2: role in doxorubicin-induced growth arrest.
    Authors: Shamseddine Et al.
    Cell Death Dis  2015;6:e1947
  2. Inhibition of protein kinase C by isojacareubin suppresses hepatocellular carcinoma metastasis and induces apoptosis in vitro and in vivo.
    Authors: Yuan Et al.
    Sci Rep  2015;5:12889
  3. Targeting a cell state common to triple-negative breast cancers.
    Authors: Muellner Et al.
    J Biol Chem  2015;11:789
  4. Systematic analysis of bacterial effector-postsynaptic density 95/disc large/zonula occludens-1 (PDZ) domain interactions demonstrates Shigella OspE protein promotes protein kinase C activation via PDLIM proteins.
    Authors: Yi Et al.
    J Neurosci  2014;289:30101
  5. A ROCK Inhibitor Blocks the Inhibitory Effect of Chondroitin Sulfate Proteoglycan on Morphological Changes of Mesenchymal Stromal/Stem Cells into Neuron-Like Cells.
    Authors: Lim and Joe
    PLoS Biol  2013;21:447
  6. Raf kinase inhibitory protein is required for cerebellar long-term synaptic depression by mediating PKC-dependent MAPK activation.
    Authors: Yamamoto Et al.
    Biomol Ther (Seoul)  2012;32:14254
  7. Identification of small molecule inhibitors of phosphatidylinositol 3-kinase and autophagy.
    Authors: Farkas Et al.
    J Biol Chem  2011;286:38904
  8. Facilitation of long-term potentiation by muscarinic M(1) receptors is mediated by inhibition of SK channels.
    Authors: Buchanan Et al.
    Neuron  2010;68:948

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