GoSlo SR 5-69

Key Product Details

Product Description

GoSlo SR 5-69 is a BK channel activator (EC₅₀ = 251 nM). Shifts the voltage required for half maximal negatively (DV_1/2 = -104 mV).

Product Specifications for GoSlo SR 5-69

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for GoSlo SR 5-69

The following data is based on the product molecular weight 470.47.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.13 mL	10.63 mL	21.26 mL
5 mM	0.43 mL	2.13 mL	4.25 mL
10 mM	0.21 mL	1.06 mL	2.13 mL
50 mM	0.04 mL	0.21 mL	0.43 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Schewe A pharmacological master key mechanism that unlocks the selectivity filter gate in K⁺ channels. Science 2019 PMID: 30792303
• Roy Development of GoSlo-SR-5-69, a potent activator of large conductance Ca²⁺-activated K⁺ (BK) channels. Eur.J.Med.Chem. 2014 PMID: 24561672

Product Documents for GoSlo SR 5-69