GP 1a

  ( 5 citations )    
Product Datasheet
Catalog Number:2764
Chemical Name:N-(Piperidin-1-yl)-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methylindeno[1,2-c]pyrazole-3-carboxamide
Product Details
Citations (5)
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Reviews
Biological Activity
CB2 receptor inverse agonist (pEC50 = 7.1), shown in cAMP, GTPγS and β-arrestin recruitment assays. Demonstrates approximately 30-fold selectivity for CB2 receptors over CB1 receptors. Increases P-ERK1/2 expression in HL-60 cells in vitro.
Technical Data
  • M.Wt:
    441.35
  • Formula:
    C23H22Cl2N4O
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >99
  • Storage:
    Store at RT
  • CAS No:
    511532-96-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for GP 1a include:

5 Citations: Showing 1 - 5
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  1. Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity.
    Authors: Soethoudt Et al.
    Nat.Commun.  2017;
  2. CB2R orchestrates fibrogenesis through regulation of inflammatory response during the repair of skeletal muscle contusion.
    Authors: Zhang Et al.
    Am J Physiol Regul Integr Comp Physiol  2015;8:3491
  3. Activation of cannabinoid receptor 2 inhibits experimental cystitis.
    Authors: Wang Et al.
    J Neuroimmune Pharmacol  2013;304:R846
  4. The anti-apoptotic Bcl-B protein inhibits BECN1-dependent autophagic cell death.
    Authors: Robert Et al.
    Int J Clin Exp Pathol  2012;8:637
  5. Cannabinoid 2 (CB2) receptor involvement in the down-regulation but not up-regulation of serum IgE levels in immunized mice.
    Authors: Newton and Klein
    PLoS One  2012;7:591

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