GPP 78 hydrochloride
Chemical Name: N-[1,1'-Biphenyl]-2-yl-4-(3-pyridinyl)-1H,1,2,3-triazole-1-octanamide hydrochloride
Biological ActivityInhibitor of nicotinamide phosphoribosyltransferase (NAMPT); potently depletes NAD levels and exhibits cytotoxicity in vitro (IC50 values are 3.0 and 3.8 nM respectively). Also shown to induce autophagy in neuroblastoma cells.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
A novel potent nicotinamide phosphoribosyltransferase inhibitor synthesized via click chemistry.
Colombano et al.
Citation for GPP 78 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for GPP 78 hydrochloride include:
1 Citation: Showing 1 - 1
PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma.
Authors: Fons Et al.
Nat Commun 2019;10:3790
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