GPP 78 hydrochloride

Tocris Bioscience | Catalog # 4835

NAMPT inhibitor; also induces autophagy
Tocris Bioscience
Discontinued Product
4835 has been discontinued. View all NAMPT Inhibitors products.

Key Product Details

Description

NAMPT inhibitor; also induces autophagy
View all NAMPT Inhibitors »

Product Description

GPP 78 hydrochloride is an inhibitor of nicotinamide phosphoribosyltransferase (NAMPT); potently depletes NAD levels and exhibits cytotoxicity in vitro (IC50 values are 3.0 and 3.8 nM respectively). Also shown to induce autophagy in neuroblastoma cells.

Product Specifications for GPP 78 hydrochloride

Molecular Weight

476.01

Formula

C27H29N5O.HCl

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

N-[1,1'-Biphenyl]-2-yl-4-(3-pyridinyl)-1H,1,2,3-triazole-1-octanamide hydrochloride

PubChem ID

90488976

InChI Key

WNZSQRVUGCAYDC-UHFFFAOYSA-N

SMILES

O=C(NC3=C(C4=CC=CC=C4)C=CC=C3)CCCCCCCN1N=NC(C2=CC=CN=C2)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 47.6 100
DMSO 47.6 100

Preparing Stock Solutions for GPP 78 hydrochloride

The following data is based on the product molecular weight 476.01.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.10 mL 10.50 mL 21.01 mL
5 mM 0.42 mL 2.10 mL 4.20 mL
10 mM 0.21 mL 1.05 mL 2.10 mL
50 mM 0.04 mL 0.21 mL 0.42 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 26 publications citing the usage of this product.

Product Documents for GPP 78 hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for GPP 78 hydrochloride

For research use only

Citations for GPP 78 hydrochloride

Customer Reviews for GPP 78 hydrochloride (1)

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  • Great inhibitor.
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: human astrocytes
    Verified Customer | Posted 05/07/2020
    After 72hr treatment with three different inhibitors (GPP78,STF118804, and STF31), we used 10nM to 10uM.
    GPP 78 hydrochloride 4835

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