GPP 78 hydrochloride

Catalog # Availability Size / Price Qty
4835/10
4835/50
Cat.No. 4835 - GPP 78 hydrochloride | C27H29N5O.HCl
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Description: NAMPT inhibitor; also induces autophagy

Chemical Name: N-[1,1'-Biphenyl]-2-yl-4-(3-pyridinyl)-1H,1,2,3-triazole-1-octanamide hydrochloride

Purity: ≥98%

Product Details
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Biological Activity

Inhibitor of nicotinamide phosphoribosyltransferase (NAMPT); potently depletes NAD levels and exhibits cytotoxicity in vitro (IC50 values are 3.0 and 3.8 nM respectively). Also shown to induce autophagy in neuroblastoma cells.

Technical Data

M.Wt:
476.01
Formula:
C27H29N5O.HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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