Inhibitor of nicotinamide phosphoribosyltransferase (NAMPT); potently depletes NAD levels and exhibits cytotoxicity in vitro
values are 3.0 and 3.8 nM respectively). Also shown to induce autophagy in neuroblastoma cells.
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A novel potent nicotinamide phosphoribosyltransferase inhibitor synthesized via click chemistry.
Colombano et al.