GPP 78 hydrochloride
Chemical Name: N-[1,1'-Biphenyl]-2-yl-4-(3-pyridinyl)-1H,1,2,3-triazole-1-octanamide hydrochloride
Biological ActivityGPP 78 hydrochloride is an inhibitor of nicotinamide phosphoribosyltransferase (NAMPT); potently depletes NAD levels and exhibits cytotoxicity in vitro (IC50 values are 3.0 and 3.8 nM respectively). Also shown to induce autophagy in neuroblastoma cells.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
A novel potent nicotinamide phosphoribosyltransferase inhibitor synthesized via click chemistry.
Colombano et al.
Citation for GPP 78 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for GPP 78 hydrochloride include:
1 Citation: Showing 1 - 1
PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma.
Authors: Fons Et al.
Nat Commun 2019;10:3790
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for GPP 78 hydrochloride
Average Rating: 5 (Based on 1 Review)
Have you used GPP 78 hydrochloride?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image