Human GPVI ELISA Kit (Colorimetric)

Key Product Details

Product Specifications

Precision

Intra-Assay Precision (Precision within an assay) %CV 10 (example only; lot dependent)

Inter-Assay Precision (Precision between assays) %CV 12 (example only; lot dependent)

Scientific Data Images for Human GPVI ELISA Kit (Colorimetric)

Kit Contents for Human GPVI ELISA Kit (Colorimetric)

• Detection Reagent A
• Detection Reagent B
• Diluent Buffer
• Instruction manual
• Plate sealer for 96 wells
• Pre-coated 96T strip plate
• Standard
• Stop Solution
• TMB Substrate
• Wash Buffer (30 x concentrate)

Preparation and Storage

Background: GPVI

Glycoprotein VI (GP6) is a 58-kD platelet membrane glycoprotein that plays a crucial role in the collagen-induced activation and aggregation of platelets. Upon injury to the vessel wall and subsequent damage to the endothelial lining, exposure of the subendothelial matrix to blood flow results in deposition of platelets. Collagen fibers are the most thrombogenic macromolecular components of the extracellular matrix, with collagen types I, III, and VI being the major forms found in blood vessels. Platelet interaction with collagen occurs as a 2-step procedure: (1) the initial adhesion to collagen is followed by (2) an activation step leading to platelet secretion, recruitment of additional platelets, and aggregation. In physiologic conditions, the resulting platelet plug is the initial hemostatic event limiting blood loss. However, exposure of collagen after rupture of atherosclerotic plaques is a major stimulus of thrombus formation associated with myocardial infarction or stroke (Jandrot-Perrus et al., 2000 (PubMed 10961879)).(supplied by OMIM)

Additional GPVI Products

• All Products for GPVI
• GPVI cDNA Clones
• GPVI ELISA Kits
• GPVI Lysates
• GPVI Primary Antibodies
• GPVI Proteins and Enzymes

Product Documents for Human GPVI ELISA Kit (Colorimetric)