Potent, selective 5-HT4
receptor antagonist (pKB
= 9.43 in human colonic muscle, and Kd
= 0.15 nM for binding to cloned human 5-HT4
receptors). Displays > 300-fold selectivity over 5-HT1A
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GR113808: a novel, selective antagonist with high affinity at the 5-HT4 receptor.
Gale et al.
Cloning and expression of a human serotonin 5-HT4 receptor cDNA.
Van den Wyngaert et al.
Central 5-HT4 receptors.
Eglen et al.
An improved in vitro bioassay for the study of 5-HT4 receptors in the human isolated large intestinal circular muscle.
Prins et al.
The citations listed below are publications that use Tocris products. Selected citations for GR 113808 include:
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