Catalog Number: 1322
Chemical Name: 1-methyl-1H-indole-3-carboxylic acid, [1-[2-[(methylsulfonyl)amino]ethyl]-4-piperidinyl]methyl ester
Biological Activity
Potent, selective 5-HT4 receptor antagonist (pKB = 9.43 in human colonic muscle, and Kd = 0.15 nM for binding to cloned human 5-HT4 receptors). Displays > 300-fold selectivity over 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2C and 5-HT3 receptors.
Technical Data
  • M.Wt:
    393.5
  • Formula:
    C19H27N3O4S
  • Solubility:
    Soluble to 25 mM in 1eq. HCl
  • Purity:
    >98%
  • Storage:
    Store at RT
  • CAS No:
    144625-51-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of GlaxoSmithKline
Background References
  1. GR113808: a novel, selective antagonist with high affinity at the 5-HT4 receptor.
    Gale et al.
    Br.J.Pharmacol., 1994;111:332
  2. Cloning and expression of a human serotonin 5-HT4 receptor cDNA.
    Van den Wyngaert et al.
    J.Neurochem., 1997;69:1810
  3. Central 5-HT4 receptors.
    Eglen et al.
    TiPS, 1995;16:391
  4. An improved in vitro bioassay for the study of 5-HT4 receptors in the human isolated large intestinal circular muscle.
    Prins et al.
    Br.J.Pharmacol., 2000;129:1601
Citations:

The citations listed below are publications that use Tocris products. Selected citations for GR 113808 include:

3 Citations: Showing 1 - 3
Filter your results:

  1. Visceral analgesic effect of 5-HT(4) receptor agonist in rats involves the rostroventral medulla (RVM).
    Authors: Sengupta Et al.
    Neuropharmacology 2014;79:345
  2. Mechanism of ghrelin-induced gastric contractions in Suncus murinus (house musk shrew): involvement of intrinsic primary afferent neurons.
    Authors: Mondal Et al.
    PLoS One 2013;8:e60365
  3. Raphé neurons stimulate respiratory circuit activity by multiple mechanisms via endogenously released serotonin and substance P.
    Authors: Ptak Et al.
    PLoS One 2009;29:3720

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