GR 113808

Key Product Details

Product Description

GR 113808 is a potent, selective 5-HT₄ receptor antagonist (pK_B = 9.43 in human colonic muscle, and K_d = 0.15 nM for binding to cloned human 5-HT₄ receptors). Displays > 300-fold selectivity over 5-HT_1A, 5-HT_1B, 5-HT_2A, 5-HT_2C and 5-HT₃ receptors.

Licensing Information

Sold with the permission of GlaxoSmithKline

Product Specifications for GR 113808

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for GR 113808

The following data is based on the product molecular weight 393.50.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	10.17 mL	50.83 mL	101.65 mL
1.25 mM	2.03 mL	10.17 mL	20.33 mL
2.5 mM	1.02 mL	5.08 mL	10.17 mL
12.5 mM	0.20 mL	1.02 mL	2.03 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 66 publications citing the usage of this product.

• Van den Wyngaert Cloning and expression of a human serotonin 5-HT₄ receptor cDNA. J.Neurochem. 1997 PMID: 9349523
• Gale GR113808: a novel, selective antagonist with high affinity at the 5-HT₄ receptor. Br.J.Pharmacol. 1994 PMID: 8012715
• Prins An improved in vitro bioassay for the study of 5-HT₄ receptors in the human isolated large intestinal circular muscle. Br.J.Pharmacol. 2000 PMID: 10780964
• Eglen Central 5-HT₄ receptors. TiPS 1995 PMID: 8578609

Product Documents for GR 113808