Catalog Number: 1322
Chemical Name: 1-methyl-1H-indole-3-carboxylic acid, [1-[2-[(methylsulfonyl)amino]ethyl]-4-piperidinyl]methyl ester
Biological Activity
Potent, selective 5-HT4 receptor antagonist (pKB = 9.43 in human colonic muscle, and Kd = 0.15 nM for binding to cloned human 5-HT4 receptors). Displays > 300-fold selectivity over 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2C and 5-HT3 receptors.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 25 mM in 1eq. HCl
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of GlaxoSmithKline
Background References
  1. GR113808: a novel, selective antagonist with high affinity at the 5-HT4 receptor.
    Gale et al.
    Br.J.Pharmacol., 1994;111:332
  2. Cloning and expression of a human serotonin 5-HT4 receptor cDNA.
    Van den Wyngaert et al.
    J.Neurochem., 1997;69:1810
  3. Central 5-HT4 receptors.
    Eglen et al.
    TiPS, 1995;16:391
  4. An improved in vitro bioassay for the study of 5-HT4 receptors in the human isolated large intestinal circular muscle.
    Prins et al.
    Br.J.Pharmacol., 2000;129:1601
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details


Contact Information

Molarity Calculator
Calculate the mass, volume or concentration required for a solution

The molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) x Volume (L) x Molecular Weight (g/mol)
An example of a molarity calculation using the molarity calculator:
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?

R&D Systems Guarantee

or select another batch:


Customer Information