GR 64349

  ( 3 citations )    
Product Datasheet
Catalog Number:1668
Chemical Name:
Product Details
Citations (3)
Supplemental Products
Reviews
Biological Activity
Potent and selective tachykinin NK2 receptor agonist (EC50 = 3.7 nM in rat colon). Displays > 1000- and > 300-fold selectivity over NK1 and NK3 receptors respectively. Active in vivo.
Technical Data
  • M.Wt:
    921.12
  • Formula:
    C42H68N10O11S
  • Sequence:
    KDSFVGLM

    (Modifications: Leu-7 = R-γ-lactam-Leu, Met-8 = C-terminal amide)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    137593-52-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from GlaxoSmithKline
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for GR 64349 include:

3 Citations: Showing 1 - 3
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  1. Direct actions of kisspeptins on GnRH neurons permit attainment of fertility but are insufficient to fully preserve gonadotropic axis activity.
    Authors: León Et al.
    Sci.Rep.  2016;6:19206
  2. The integrated hypothalamic tachykinin-kisspeptin system as a central coordinator for reproduction.
    Authors: Navarro Et al.
    Sci Rep  2015;156:627
  3. Effects and interactions of tachykinins and dynorphin on FSH and LH secretion in developing and adult rats.
    Authors: Ruiz-Pino Et al.
    Endocrinology  2015;156:576

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