Catalog Number: 1483
Chemical Name: 4-[(3,4-Dichlorophenyl)acetyl]-3-(1-pyrrolidinylmethyl)-1-piperazinecarboxylic acid methyl ester fumarate
Biological Activity
Highly potent and selective κ-opioid agonist (IC50 = 0.04 nM) that may be selective for the putative κ2 receptor. Anti-nociceptive and neuroprotective in vivo.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 25 mM in water with gentle warming and to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Neuroprotective actions of GR89696, a highly potent and selective κ-opioid receptor agonist.
    Birch et al.
    Br.J.Pharmacol., 1991;103:1819
  2. GR89,696: a potent κ-opioid agonist with subtype selectivity in rhesus monkeys.
    Butelman et al.
    J.Pharmacol.Exp.Ther., 2001;298:1049
  3. A potent new class of κ-receptor agonist: 4-substituted 1-(arylacetyl)-2-[(dialkylamino)methyl]piperazines.
    Naylor et al.
    J.Med.Chem., 1993;36:2075
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