Catalog Number: 2903
Alternate Names: BRL 43694
Chemical Name: 1-Methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-1H-indazole-3-carboxamide hydrochloride
Biological Activity
5-HT3 receptor antagonist that possesses potent antiemetic activity.
Technical Data
  • M.Wt:
    348.87
  • Formula:
    C18H24N4O.HCl
  • Solubility:
    Soluble to 100 mM in water and to 10 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    107007-99-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Selective and functional 5-hydroxytryptamine3 receptor antagonism by BRL 43694 (granisetron).
    Sanger and Nelson
    Eur.J.Pharmacol., 1989;159:113
  2. Granisetron. A review of its pharmacological properties and therapeutic use as an antiemetic.
    Plosker and Goa
    Drugs, 1991;42:805
  3. Anti-emetic effect of Ondansetron and Granisetron after exposure to mixed neutron and gamma irradiation.
    Martin et al.
    Rad.Res., 1998;149:631
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Granisetron hydrochloride include:

2 Citations: Showing 1 - 2
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  1. Development of Plate Reader and On-Line Microfluidic Screening to Identify Ligands of the 5-Hydroxytryptamine Binding Protein in Venoms.
    Authors: Otvos Et al.
    Neuropharmacology 2015;7:2336
  2. Pronociceptive and Antinociceptive Effects of Buprenorphine in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude.
    Authors: Gerhold Et al.
    J Neurosci 2015;35:9580

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