Chemical Name: 1-Methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-1H-indazole-3-carboxamide hydrochloride
Biological ActivityGranisetron hydrochloride is a 5-HT3 receptor antagonist that possesses potent antiemetic activity.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Selective and functional 5-hydroxytryptamine3 receptor antagonism by BRL 43694 (granisetron).
Sanger and Nelson
Granisetron. A review of its pharmacological properties and therapeutic use as an antiemetic.
Plosker and Goa
Anti-emetic effect of ondans. and granis. after exposure to mixed neutron and gamma irradiation.
Martin et al.
Citations for Granisetron hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Granisetron hydrochloride include:
4 Citations: Showing 1 - 4
Development of Plate Reader and On-Line Microfluidic Screening to Identify Ligands of the 5-Hydroxytryptamine Binding Protein in Venoms.
Authors: Otvos Et al.
Pronociceptive and Antinociceptive Effects of Bupren. in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude.
Authors: Gerhold Et al.
J Neurosci 2015;35:9580
Unique ionotropic receptors for D-aspartate are a target for serotonin-induced synaptic plasticity in Aplysia californica.
Authors: Carlson and Fieber
Comp Biochem Physiol C Toxicol Pharmacol 2012;155:151
Polysynaptic excitatory postsynaptic potentials that trigger spasms after spinal cord injury in rats are inhibited by 5-HT1B and 5-HT1F receptors.
Authors: Murray Et al.
J Neurophysiol 2011;106:925
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