GRASP1 Antibody Summary
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Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Detection of GRASP by Western Blot. Western blot of rat cerebellar lysate showing the specific immunolabeling of the approximately 95 kDa GRASP protein.
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PDZ domain-containing proteins, such as PSD-95 and GRIP are thought to play key roles in glutamate receptor plasticity. GRIP-associated proteins (GRASPs) that bind to distinct PDZ domains within GRIP also play key roles in regulation of glutamate receptor function. GRASP-1 is a neuronal rasGEF associated with GRIP and AMPA receptors in vivo. Recent work suggests that GRASP-1 may regulate neuronal ras signaling and contribute to the regulation of AMPA receptor distribution by NMDA receptor activity.
- Scannevin, R.H. and R.L. Huganir (2000) Nat. Rev. Neurosci. 1:133.
- Ye, B. et al. (2000) Neuron 26:603.
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