GRASP1 Antibody

  
  • Species Reactivity
    Human, Mouse, Rat, Bovine, Canine
  • Specificity
    This antibody is specific for the 95 kDa GRASP in Western blots of rat cerebellar lysates.
  • Source
    Polyclonal Rabbit IgG
  • Purification
    Antigen Affinity-purified
  • Immunogen
    Peptide corresponding to amino acid residues from the C‑terminal region of rat GRASP, conjugated to keyhole limpet hemocyanin (KLH)
  • Formulation
    100 μL in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50% glycerol.
  • Label
    Unconjugated
Applications
  •  
    Recommended
    Concentration
    Sample
  • Western Blot
    1:1000 dilution
    See below
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Data Examples
Detection of GRASP by Western Blot. Western blot of rat cerebellar lysate showing the specific immunolabeling of the approximately 95 kDa GRASP protein.
Preparation and Storage
  • Shipping
    The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
  • Stability & Storage
    For long-term storage, ≤‑20° C is recommended. Product is stable at ≤ ‑20° C for at least 1 year.
Background: GRASP1
PDZ domain-containing proteins, such as PSD-95 and GRIP are thought to play key roles in glutamate receptor plasticity. GRIP-associated proteins (GRASPs) that bind to distinct PDZ domains within GRIP also play key roles in regulation of glutamate receptor function. GRASP-1 is a neuronal rasGEF associated with GRIP and AMPA receptors in vivo. Recent work suggests that GRASP-1 may regulate neuronal ras signaling and contribute to the regulation of AMPA receptor distribution by NMDA receptor activity.
  • References:
    1. Scannevin, R.H. and R.L. Huganir (2000) Nat. Rev. Neurosci. 1:133.
    2. Ye, B. et al. (2000) Neuron 26:603.
  • Long Name:
    GRIP1 Associated Protein 1
  • Entrez Gene IDs:
    56850 (Human); 54645 (Mouse); 116493 (Rat)
  • Alternate Names:
    DKFZp434P0630; GRASP1; GRASP-1MGC126595; GRIP1 associated protein 1; GRIP1-associated protein 1; GRIPAP1; KIAA1167MGC126593; MPMGp800B12492Q3
Related Research Areas
Isotype Controls
Description Application Cat# Citations Images  

Normal Rabbit IgG Control

Ctrl AB-105-C 43  
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Normal Rabbit IgG Control

Ctrl, CyTOF-ready MAB1050  
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Secondary Antibodies
Description Application Cat# Citations Images  

Rabbit IgG HRP-conjugated Antibody

WB HAF008 23  
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Donkey Anti-Rabbit IgG NorthernLights™ NL557-conjugated Antibody

Flow, IHC, ICC NL004 10
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Donkey Anti-Rabbit IgG NorthernLights™ NL637-conjugated Antibody

Flow, IHC, ICC NL005 2
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Rabbit IgG APC-conjugated Antibody

Flow F0111 1  
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Rabbit IgG PE-conjugated Antibody

Flow F0110 2  
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Donkey Anti-Rabbit IgG NorthernLights™ NL493-conjugated Antibody

Flow, IHC, ICC NL006 4
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Rabbit IgG Fluorescein-conjugated Antibody

Flow F0112 5  
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Goat Anti-Rabbit IgG Biotinylated Antibody

WB BAF008 4
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Mouse/Rabbit IgG VisUCyte HRP Polymer Antibody

IHC VC002  
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Rabbit IgG VisUCyte HRP Polymer Antibody

IHC VC003  
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Rabbit IgG Antibody

WB AF008 1
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Donkey Anti-Rabbit IgG (H+L) Antibody

D-301-C-ABS2
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