GRASP1 Antibody

R&D Systems | Catalog # PPS052

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Key Product Details

Species Reactivity

Human, Mouse, Rat, Bovine, Canine

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG
View all GRASP1 Primary Antibodies »

Product Specifications

Immunogen

Peptide corresponding to amino acid residues from the C‑terminal region of rat GRASP, conjugated to keyhole limpet hemocyanin (KLH)

Specificity

This antibody is specific for the 95 kDa GRASP in Western blots of rat cerebellar lysates.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for GRASP1 Antibody

Detection of GRASP antibody by Western Blot.

Detection of GRASP by Western Blot.

Western blot of rat cerebellar lysate showing the specific immunolabeling of the approximately 95 kDa GRASP protein.

Applications for GRASP1 Antibody

Application
Recommended Usage

Western Blot

1:1000 dilution
Sample: Rat brain (cerebellum) lysate

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Formulation

100 μL in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50% glycerol.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

For long-term storage, ≤‑20° C is recommended. Product is stable at ≤ ‑20° C for at least 1 year.

Background: GRASP1

PDZ domain-containing proteins, such as PSD-95 and GRIP are thought to play key roles in glutamate receptor plasticity. GRIP-associated proteins (GRASPs) that bind to distinct PDZ domains within GRIP also play key roles in regulation of glutamate receptor function. GRASP-1 is a neuronal rasGEF associated with GRIP and AMPA receptors in vivo. Recent work suggests that GRASP-1 may regulate neuronal ras signaling and contribute to the regulation of AMPA receptor distribution by NMDA receptor activity.

References

  1. Scannevin, R.H. and R.L. Huganir (2000) Nat. Rev. Neurosci. 1:133.
  2. Ye, B. et al. (2000) Neuron 26:603.

Long Name

GRIP1 Associated Protein 1

Alternate Names

GRIPAP1

Entrez Gene IDs

56850 (Human); 54645 (Mouse); 116493 (Rat)

Gene Symbol

GRIPAP1

Additional GRASP1 Products

Product Documents for GRASP1 Antibody

Certificate of Analysis

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Note: Certificate of Analysis not available for kit components.

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Product Specific Notices for GRASP1 Antibody

For research use only

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