GRI 977143

Tocris Bioscience | Catalog # 4779

Selective LPA2 receptor non-lipid agonist
Tocris Bioscience

Key Product Details

Description

Selective LPA2 receptor non-lipid agonist
View all Lysophosphatidic Acid (LPA) Receptor Agonists »

Product Description

GRI 977143 is a selective lysophosphatidic acid 2 (LPA2) receptor non-lipid agonist (EC50 = 3.3 μM). Does not activate other LPA GPCRs at concentrations up to 10 μM. Antiapoptotic; inhibits activation of caspases 3, 7, 8 and 9, Bax translocation and PARP-1 cleavage. Activates ERK1/2 survival pathway.

Product Specifications for GRI 977143

Molecular Weight

391.44

Formula

C22H17NO4S

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

2-[[3-(1,3-dioxo-1H-benz[de]isoquinolin-2(3H)-yl)propyl]thio]benzoic acid

CAS Number

325850-81-5

PubChem ID

3114900

InChI Key

GMVZUCHUOYUMLL-UHFFFAOYSA-N

SMILES

O=C(C2=CC=CC3=CC=CC(C4=O)=C23)N4CCCSC1=CC=CC=C1C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.14 100

Preparing Stock Solutions for GRI 977143

The following data is based on the product molecular weight 391.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.55 mL 12.77 mL 25.55 mL
5 mM 0.51 mL 2.55 mL 5.11 mL
10 mM 0.26 mL 1.28 mL 2.55 mL
50 mM 0.05 mL 0.26 mL 0.51 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for GRI 977143

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for GRI 977143

For research use only

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