Catalog Number: 4779
Chemical Name: 2-[[3-(1,3-dioxo-1H-benz[de]isoquinolin-2(3H)-yl)propyl]thio]benzoic acid
Biological Activity
Selective lysophosphatidic acid 2 (LPA2) receptor non-lipid agonist (EC50 = 3.3 μM). Does not activate other LPA GPCRs at concentrations up to 10 μM. Antiapoptotic; inhibits activation of caspases 3, 7, 8 and 9, Bax translocation and PARP-1 cleavage. Activates ERK1/2 survival pathway.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Virtual screening for LPA2-specific agonists identifies a nonlipid compound with antiapoptotic actions.
    Kiss et al.
    Mol.Pharmacol., 2012;82:1162
  2. Mitigation of radiation injury by selective stimulation of the LPA(2) receptor.
    Kiss et al.
    Biochim.Biophys.Acta, 2013;1831:117
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