GRI 977143

Catalog # Availability Size / Price Qty
4779/10
4779/50
Cat.No. 4779 - GRI 977143 | C22H17NO4S | CAS No. 325850-81-5
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Description: Selective LPA2 receptor non-lipid agonist

Chemical Name: 2-[[3-(1,3-dioxo-1H-benz[de]isoquinolin-2(3H)-yl)propyl]thio]benzoic acid

Purity: ≥98%

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Biological Activity

Selective lysophosphatidic acid 2 (LPA2) receptor non-lipid agonist (EC50 = 3.3 μM). Does not activate other LPA GPCRs at concentrations up to 10 μM. Antiapoptotic; inhibits activation of caspases 3, 7, 8 and 9, Bax translocation and PARP-1 cleavage. Activates ERK1/2 survival pathway.

Technical Data

M.Wt:
391.44
Formula:
C22H17NO4S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
325850-81-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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