Biological ActivityGRK2 inhibitory polypeptide that specifically inhibits Gβγ activation of GRK2. Corresponds to the Gβγ-binding domain and acts as a cellular Gβγ antagonist.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Cellular expression of the carboxyl terminus of a G protein-coupled receptor kinase attenuates Gβγ-mediated signaling.
Koch et al.
A βγ dimer derived from G13 transduces the angiotensin AT1 receptor signal to stimulation of Ca2+ channels in rat portal vein myocytes.
Macrez et al.
Two distinct mechanisms mediate acute μ-opioid receptor desensitization in native neurons.
Dang et al.
Citations for GRK2i
The citations listed below are publications that use Tocris products. Selected citations for GRK2i include:
2 Citations: Showing 1 - 2
G-protein βγ subunits are positive regulators of Kv7.4 and native vascular Kv7 channel activity.
Authors: Stott Et al.
Nerve growth factor induces neurite outgrowth of PC12 cells by promoting Gβγ-microtubule interaction.
Authors: Sierra-Fonseca Et al.
BMC Neurosci 2014;15:132
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