Catalog Number: 3594
Biological Activity
GRK2 inhibitory polypeptide that specifically inhibits Gβγ activation of GRK2. Corresponds to the Gβγ-binding domain and acts as a cellular Gβγ antagonist.
Technical Data
  • M.Wt:
    3484.08
  • Formula:
    C153H256N50O41S
  • Sequence:
    WKKELRDAYREAQQLVQRVPKMKNKPRS
  • Solubility:
    Soluble to 2 mg/ml in water
  • Storage:
    Store at -20°C
  • CAS No:
    148505-03-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Cellular expression of the carboxyl terminus of a G protein-coupled receptor kinase attenuates Gβγ-mediated signaling.
    Koch et al.
    J.Biol.Chem., 1994;269:6193
  2. A βγ dimer derived from G13 transduces the angiotensin AT1 receptor signal to stimulation of Ca2+ channels in rat portal vein myocytes.
    Macrez et al.
    J.Biol.Chem., 1997;272:23180
  3. Two distinct mechanisms mediate acute μ-opioid receptor desensitization in native neurons.
    Dang et al.
    J.Neurosci., 2009;29:3322
Citations:

The citations listed below are publications that use Tocris products. Selected citations for GRK2i include:

1 Citations: Showing 1 - 1

  1. G-protein βγ subunits are positive regulators of Kv7.4 and native vascular Kv7 channel activity.
    Authors: Stott Et al.
    Apoptosis 2015;112:6497

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