GRP (human)

Name: GRP (human)
Brand: Tocris Bioscience
SKU: 1789
Price: 401 USD
Availability: InStock

Tocris Bioscience | Catalog # 1789

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Citations (7)

Product Documents

Endogenous GRP receptor agonist

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Endogenous GRP receptor agonist

Alternative Names

Gastrin-releasing peptide (human)

View all Bombesin Receptor Agonists »

Product Description

GRP (human) is a mammalian bombesin-like peptide neurotransmitter that is an agonist for the gastrin-releasing peptide receptor (GRPR). GRP has been reported to activate GABAergic interneurons in the amygdala leading to increased GABA release and fear suppression in mice in vivo. Also involved in mitogenesis, and GI tract and appetite regulation.

Product Specifications for GRP (human)

Molecular Weight

2859.40

Formula

C₁₃₀H₂₀₄N₃₈O₃₁S₂

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

93755-85-2

PubChem ID

16143985

InChI Key

PUBCCFNQJQKCNC-XKNFJVFFSA-N

SMILES

[H]N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)NCC(=O)NCC(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 1mg/ml in water

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 7 publications citing the usage of this product.

Woodruff Bombesin receptors in the brain. Ann.N.Y.Acad.Sci. 1996 PMID: 8602736
Dudai Neurobiology: Fear thou not. Nature 2003 PMID: 12540884
Shumyatsky Identification of a signaling network in lateral nucleus of amygdala important for inhibiting memory specifically related to learned fear. Cell 2002 PMID: 12526815
Benya Expression and characterization of cloned human bombesin receptors. Mol.Pharmacol. 1995 PMID: 7838118

Product Documents for GRP (human)

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Download SDS

Product Specific Notices for GRP (human)

For research use only

Citations for GRP (human)

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