Biological ActivityGRP (human) is a mammalian bombesin-like peptide neurotransmitter that is an agonist for the gastrin-releasing peptide receptor (GRPR). GRP has been reported to activate GABAergic interneurons in the amygdala leading to increased GABA release and fear suppression in mice in vivo. Also involved in mitogenesis, and GI tract and appetite regulation.
(Modifications: Met-27 = C-terminal amide)
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Expression and characterization of cloned human bombesin receptors.
Benya et al.
Neurobiology: Fear thou not.
Identification of a signaling network in lateral nucleus of amygdala important for inhibiting memory specifically related to learned fear.
Shumyatsky et al.
Bombesin receptors in the brain.
Woodruff et al.
Citations for GRP (human)
The citations listed below are publications that use Tocris products. Selected citations for GRP (human) include:
6 Citations: Showing 1 - 6
The neurokinin-1 receptor is expressed with gastrin-releasing peptide receptor in spinal interneurons and modulates itch.
Authors: Shehan Et al.
J Neurosci 2020;40:8816
Gastrin-releasing peptide receptor mediates the excitation of preoptic GABAergic neurons by bombesin
Authors: Blais Et al.
Neuroscience Letters 2016;633:262
Atf3 mutant mice show reduced axon regeneration and impaired regeneration-associated gene induction after peripheral nerve injury.
Authors: Gey Et al.
Open Biol 2016;6
Distinct functions of opioid-related peptides and gastrin-releasing peptide in regulating itch and pain in the spinal cord of primates.
Authors: Lee and Ko
Int J Inflam 2015;5:11676
Primary afferent and spinal cord expression of gastrin-releasing peptide: message, protein, and antibody concerns.
Authors: Solorzano Et al.
Sci Rep 2015;35:648
Enhanced autophagy blocks angiogenesis via degradation of gastrin-releasing peptide in neuroblastoma cells.
Authors: Kim Et al.
J Neurosci 2013;9:1579
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