GS 143

Catalog # Availability Size / Price Qty
Cat.No. 5636 - GS 143 | C28H19FN2O4 | CAS No. 916232-21-8
1 Image
Description: β-TrCP1 ligase inhibitor

Chemical Name: 4-[4-[[5-(2-Fluorophenyl)-2-furanyl]methylene]-4,5-dihydro-5-oxo-3-(phenylmethyl)-1H-pyrazol-1-yl]benzoic acid

Product Details

Biological Activity

β-TrCP1 ligase inhibitor. Inhibits IκBα ubiquitination (IC50 = 5.2 μM) without affecting proteasome activity. Blocks LPS-induced expression of inflammatory cytokines in human myelomonocytic cells. Suppresses antigen-induced NFκB expression, inflammation and mucus production in airways of OVA-sensitized mice.

Technical Data

Soluble to 100 mM in DMSO
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Background References

  1. GS143, an IκB ubiquitination inhibitor, inhibits allergic airway inflammation in mice.
    Hirose et al.
    Biochem.Biophys.Res.Comm., 2008;374:507
  2. A novel small-molecule inhibitor of NF-κB signaling.
    Nakajima et al.
    Biochem.Biophys.Res.Comm., 2008;368:1007

Product Datasheets

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.



No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for GS 143

There are currently no reviews for this product. Be the first to review GS 143 and earn rewards!

Have you used GS 143?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.