GS 6201

Key Product Details

Product Description

GS 6201 is a selective antagonist of adenosine A_2B receptors (K_i values are 22, 1070, 1940 and 3280 nM for human A_2B, A₃, A₁ and A_2A receptors respectively). Attenuates allergen-, NECA- and AMP-induced airway reactivity in an allergic mouse model of asthma. Also shown to attenuate the inflammatory response during acute myocardial infarction in mice; reduces caspase-1 activity in the heart.

Product Specifications for GS 6201

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for GS 6201

The following data is based on the product molecular weight 446.43.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.05 mM	44.80 mL	224.00 mL	448.00 mL
0.25 mM	8.96 mL	44.80 mL	89.60 mL
0.5 mM	4.48 mL	22.40 mL	44.80 mL
2.5 mM	0.90 mL	4.48 mL	8.96 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 7 publications citing the usage of this product.

• Toldo GS-6201, a selective blocker of the A_2B adenosine receptor, attenuates cardiac remodeling after acute myocardial infarction in the mouse. J.Pharmacol.Exp.Ther. 2012 PMID: 22923737
• Mustafa Effect of a specific and selective A_2B adenosine receptor antagonist on adenosine agonist AMP and allergen-induced airway responsiveness and cellular influx in a mouse model of asthma. J.Pharmacol.Exp.Ther. 2007 PMID: 17159162
• Elzein Discovery of a novel A_2B adenosine receptor antagonist as a clinical candidate for chronic inflammatory airway diseases. J.Med.Chem. 2008 PMID: 18321039

Product Documents for GS 6201