Selective antagonist of adenosine A2B
values are 22, 1070, 1940 and 3280 nM for human A2B
receptors respectively). Attenuates allergen-, NECA- and AMP-induced airway reactivity in an allergic mouse model of asthma. Also shown to attenuate the inflammatory response during acute myocardial infarction in mice; reduces caspase-1 activity in the heart.
Soluble to 5 mM in DMSO
Store at -20°C
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All Tocris products are intended for laboratory research use only.
Discovery of a novel A2B adenosine receptor antagonist as a clinical candidate for chronic inflammatory airway diseases.
Elzein et al.
GS-6201, a selective blocker of the A2B adenosine receptor, attenuates cardiac remodeling after acute myocardial infarction in the mouse.
Toldo et al.
Effect of a specific and selective A2B adenosine receptor antagonist on adenosine agonist AMP and allergen-induced airway responsiveness and cellular influx in a mouse model of asthma.
Mustafa et al.
The citations listed below are publications that use Tocris products. Selected citations for GS 6201 include:
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