GSK 0660

  ( 15 citations )    
Product Datasheet
Catalog Number:3433
Chemical Name:3-[[[2-Methoxy-4-(phenylamino)phenyl]amino]sulfonyl]-2-thiophenecarboxylic acid methyl ester
Product Details
Citations (15)
Supplemental Products
Reviews
Biological Activity
Selective PPARδ antagonist (IC50 values are 0.155, > 10 and 10 μM at PPARδ, PPARα and PPARγ respectively). Exhibits inverse agonist effects when administered by itself.
Technical Data
  • M.Wt:
    418.49
  • Formula:
    C19H18N2O5S2
  • Solubility:
    Soluble to 100 mM in DMSO and to 10 mM in ethanol
  • Purity:
    >99
  • Storage:
    Store at +4°C
  • CAS No:
    1014691-61-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for GSK 0660 include:

15 Citations: Showing 1 - 10
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  1. Development of PPAR-agonist GW0742 as antidiabetic drug: study in animals.
    Authors: Niu Et al.
    Drug Des Devel Ther  2015;9:5625
  2. Development of telmisartan in the therapy of spinal cord injury: pre-clinical study in rats.
    Authors: Lin Et al.
    Invest Ophthalmol Vis Sci  2015;9:4709
  3. RNA-seq identifies a role for the PPARβ/δ inverse agonist GSK0660 in the regulation of TNFα-induced cytokine signaling in retinal endothelial cells.
    Authors: Savage Et al.
    Mol Vis  2015;21:568
  4. Activation of PPAR-δ induces microRNA-100 and decreases the uptake of very low-density lipoprotein in endothelial cells.
    Authors: Fang Et al.
    Br J Pharmacol  2015;172:3728
  5. Peroxisomes in Different Skeletal Cell Types during Intramembranous and Endochondral Ossification and Their Regulation during Osteoblast Differentiation by Distinct Peroxisome Proliferator-Activated Receptors.
    Authors: Qian Et al.
    PLoS One  2015;10:e0143439
  6. Mechanisms of Nifedipine-Downregulated CD40L/sCD40L Signaling in Collagen Stimulated Human Platelets.
    Authors: Chen Et al.
    PLoS One  2015;10:e0127054
  7. Modulation of VEGF-induced retinal vascular permeability by peroxisome proliferator-activated receptor-β/δ.
    Authors: Suarez Et al.
    Invest Ophthalmol Vis Sci  2014;55:8232
  8. An endoplasmic reticulum stress-initiated sphingolipid metabolite, ceramide-1-phosphate, regulates epithelial innate immunity by stimulating β-defensin production.
    Authors: Kim Et al.
    Mol Cell Biol  2014;34:4368
  9. Merit of ginseng in the treatment of heart failure in type 1-like diabetic rats.
    Authors: Tsai Et al.
    Biochem J  2014;2014:484161
  10. Decrease of PPARδ in Type-1-Like Diabetic Rat for Higher Mortality after Spinal Cord Injury.
    Authors: Tsai Et al.
    PPAR Res  2014;2014:456386
  11. Antiplatelet activity of nifedipine is mediated by inhibition of NF-κB activation caused by enhancement of PPAR-β/-γ activity.
    Authors: Shih Et al.
    Br J Pharmacol  2014;171:1490
  12. PPARβ/δ regulates glucocorticoid- and sepsis-induced FOXO1 activation and muscle wasting.
    Authors: Castillero Et al.
    PLoS One  2013;8:e59726
  13. Peroxisome proliferator-activated receptor-β/δ regulates angiogenic cell behaviors and oxygen-induced retinopathy.
    Authors: Capozzi Et al.
    Biomed Res Int  2013;54:4197
  14. Isorhamnetin inhibits proliferation and invasion and induces apoptosis through the modulation of peroxisome proliferator-activated receptor γ activation pathway in gastric cancer.
    Authors: Ramachandran Et al.
    J Biol Chem  2012;287:38028
  15. Lipolytic products activate peroxisome proliferator-activated receptor (PPAR) α and δ in brown adipocytes to match fatty acid oxidation with supply.
    Authors: Mottillo Et al.
    Drug Des Devel Ther  2012;287:25038
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VersaClone cDNA Plasmids
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Human PPAR delta/NR1C2 (NP_006229) VersaClone cDNA

RDC2078
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