GSK 0660

Key Product Details

Product Description

GSK 0660 is a selective PPARδ antagonist (IC₅₀ values are 0.155, > 10 and ≥ 10 μM at PPARδ, PPARα and PPARγ respectively). Exhibits inverse agonist effects when administered by itself.

Product Specifications for GSK 0660

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for GSK 0660

The following data is based on the product molecular weight 418.49.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.39 mL	11.95 mL	23.90 mL
5 mM	0.48 mL	2.39 mL	4.78 mL
10 mM	0.24 mL	1.19 mL	2.39 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 40 publications citing the usage of this product.

• Wang PPAR-δ in vascular pathophysiology. PPAR Res. 2008 PMID: 19132133
• Bishop-Bailey and Swales The role of PPARs in the endothelium: Implications for cancer therapy. PPAR Res. 2008 PMID: 19043612
• Shearer Identification and characterization of a selective peroxisome proliferator-activated receptor β/δ (NR1C2) antagonist. Mol.Endocrinol. 2008 PMID: 17975020

Product Documents for GSK 0660