Catalog Number: 3433
Chemical Name: 3-[[[2-Methoxy-4-(phenylamino)phenyl]amino]sulfonyl]-2-thiophenecarboxylic acid methyl ester
Biological Activity
Selective PPARδ antagonist (IC50 values are 0.155, > 10 and 10 μM at PPARδ, PPARα and PPARγ respectively). Exhibits inverse agonist effects when administered by itself.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 10 mM in ethanol
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Identification and characterization of a selective peroxisome proliferator-activated receptor β/δ (NR1C2) antagonist.
    Shearer et al.
    Mol.Endocrinol., 2008;22:523
  2. PPAR-δ in vascular pathophysiology.
    PPAR Res., 2008;:164163
  3. The role of PPARs in the endothelium: Implications for cancer therapy.
    Bishop-Bailey and Swales
    PPAR Res., 2008;:904851
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