GSK 1562590 hydrochloride

Tocris Bioscience | Catalog # 5110

High affinity, selective urotensin II (UT) receptor antagonist
Tocris Bioscience

Key Product Details

Description

High affinity, selective urotensin II (UT) receptor antagonist
View all Urotensin-II Receptor Antagonists »

Product Description

GSK 1562590 hydrochloride is a high affinity and selective urotensin II (UT) receptor antagonist (pKi values are 9.14, 9.28, 9.34, 9.64 and 9.66 at monkey, human, mouse, cat and rat recombinant receptors respectively). Exhibits selectivity for UT receptors over a range of GPCRs, ion channels, enzymes and neurotransmitter transporters. Supresses human urotensin-II (hU-II)-induced contraction of isolated rat aorta in vitro and ex vivo. Inhibits the hU-II-induced increase in mean blood pressure in vivo. Orally active.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline.

Product Specifications for GSK 1562590 hydrochloride

Molecular Weight

617.95

Formula

C30H30Cl2N4O4.HCl

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

N-[(1R)-1-[3'-(Aminocarbonyl)[1,1'-biphenyl]-4-yl]-2-(1-pyrrolidinyl)ethyl]-6,7-dichloro-2,3-dihydro-N-methyl-3-oxo-4H-1,4-benzoxazine-4-acetamide hydrochloride

CAS Number

1003878-07-6

PubChem ID

46909864

InChI Key

XTVXEMMIPYMBLL-SNYZSRNZSA-N

SMILES

NC(C1=CC=CC(C2=CC=[C@@]([C@@H](N(C(CN4C(C=C(Cl)C(Cl)=C5)=C5OCC4=O)=O)C)CN3CCCC3)C=C2)=C1)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 61.8 100

Preparing Stock Solutions for GSK 1562590 hydrochloride

The following data is based on the product molecular weight 617.95.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.62 mL 8.09 mL 16.18 mL
5 mM 0.32 mL 1.62 mL 3.24 mL
10 mM 0.16 mL 0.81 mL 1.62 mL
50 mM 0.03 mL 0.16 mL 0.32 mL

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Background References

References are publications that support the biological activity of the product.

Product Documents for GSK 1562590 hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for GSK 1562590 hydrochloride

For research use only

Citations for GSK 1562590 hydrochloride

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